4-benzyl 1,1-di-tert-butyl butane-1,1,4-tricarboxylate

Base Information

• Chemical Name: 4-benzyl 1,1-di-tert-butyl butane-1,1,4-tricarboxylate
• CAS No.: 168975-95-9
• Molecular Formula: C₂₂H₃₂O₆
• Molecular Weight: 392.492
• Mol file: 168975-95-9.mol

Synonyms:4-benzyl 1,1-di-tert-butyl butane-1,1,4-tricarboxylate

Chemical Property of 4-benzyl 1,1-di-tert-butyl butane-1,1,4-tricarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-benzyl 1,1-di-tert-butyl butane-1,1,4-tricarboxylate

There total 3 articles about 4-benzyl 1,1-di-tert-butyl butane-1,1,4-tricarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

t-butyl malonate (541-16-2) + benzyl 4-bromobutanoate (126430-46-4) → 4-benzyl 1,1-di-tert-butyl butane-1,1,4-tricarboxylate (168975-95-9)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) DMF, RT, 30 min, 2.) DMF, RT, 18 h;

DOI:10.3987/COM-95-7024

Reference yield:

benzyl alcohol (100-51-6,185532-71-2) → 4-benzyl 1,1-di-tert-butyl butane-1,1,4-tricarboxylate (168975-95-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2.5 h / 20 °C

2.1: sodium hydride / tetrahydrofuran / 0.33 h / 20 °C

2.2: 18 h / 20 °C

With dmap; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane;

Reference yield:

→ 4-benzyl 1,1-di-tert-butyl butane-1,1,4-tricarboxylate (168975-95-9)

Guidance literature:

With sodium hydride; In tetrahydrofuran; mineral oil; for 0.416667h; Cooling with ice;

In tetrahydrofuran; mineral oil; at 20 ℃; for 18h;

upstream raw materials:

t-butyl malonate

benzyl 4-bromobutanoate

benzyl alcohol