METHYL 2-ISOCYANO-3-METHYLBUTYRATE

Base Information

Chemical Name:METHYL 2-ISOCYANO-3-METHYLBUTYRATE
CAS No.:40846-66-0
Molecular Formula:C₇H₁₁NO₂
Molecular Weight:141.17
Hs Code.:
Mol file:40846-66-0.mol

Synonyms:Butyricacid, 2-isocyano-3-methyl-, methyl ester (7CI);Methyl2-isocyano-3-methylbutanoate;Methyl 2-isocyanoisovalerate;

Suppliers and Price of METHYL 2-ISOCYANO-3-METHYLBUTYRATE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
METHYL-2-ISOCYANOISOVALERATE 96.00%
5G
$ 1357.13

Total 7 raw suppliers

Chemical Property of METHYL 2-ISOCYANO-3-METHYLBUTYRATE

Chemical Property:

Appearance/Colour:clear yellowish liquid
Refractive Index:1.422-1.424
Boiling Point:63 °C (6.0008 mmHg)
PSA：26.30000
Density:0.87
LogP:0.33400
Storage Temp.:Refrigerator (+4°C)

Purity/Quality:

99% ^*data from raw suppliers

METHYL-2-ISOCYANOISOVALERATE 96.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 36/37/38-20/21/22
Safety Statements: 36/37/39-26

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of METHYL 2-ISOCYANO-3-METHYLBUTYRATE

There total 5 articles about METHYL 2-ISOCYANO-3-METHYLBUTYRATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 3154-46-9
(S)-methyl 2-formamido-3-methylbutanoate

: 63472-88-8,100101-29-9,40846-66-0
methyl 2-isocyano-3-methylbutyrate

Guidance literature:: With diisopropylamine; trichlorophosphate; In dichloromethane;
DOI:10.1055/s-1985-31216

Reference yield:

: 3154-46-9,112383-26-3
Formyl-DL-valyl-methylester

: 63472-88-8,100101-29-9,40846-66-0
methyl 2-isocyano-3-methylbutyrate

Guidance literature:: With pyridine; p-toluenesulfonyl chloride;
DOI:10.1021/jo01017a045

Reference yield:

: 5619-05-6,6306-52-1,7146-15-8
DL-valine methyl ester hydrochloride

: 63472-88-8,100101-29-9,40846-66-0
methyl 2-isocyano-3-methylbutyrate

Guidance literature:: Multi-step reaction with 2 steps

1.1: dicyclohexyl-carbodiimide / dichloromethane / 0.17 h / 0 °C

1.2: 20 °C

2.1: triethylamine; trichlorophosphate / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

With triethylamine; dicyclohexyl-carbodiimide; trichlorophosphate; In tetrahydrofuran; dichloromethane;
DOI:10.1039/c4cc06683a