5'-O-(4,4'-DIMETHOXYTRITYL)-2'-*DEOXYGUA NOSINE

Base Information

• Chemical Name: 5'-O-(4,4'-DIMETHOXYTRITYL)-2'-*DEOXYGUA NOSINE
• CAS No.: 81144-43-6
• Molecular Formula: C31H31 N5 O6
• Molecular Weight: 569.617
• Hs Code.: 2914790090
• Mol file: 81144-43-6.mol

Synonyms:5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyguanosine;5'-O-(Dimethoxytrityl)-2'-deoxyguanosine

Chemical Property of 5'-O-(4,4'-DIMETHOXYTRITYL)-2'-*DEOXYGUA NOSINE

Chemical Property:

• PSA: 146.74000
• LogP: 3.95730
• Storage Temp.: Store dry at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-9-((2R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-1H-purin-6(9H)-one 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 23/24/25-36/37/38
• Safety Statements: 22-26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5'-O-(4,4'-DIMETHOXYTRITYL)-2'-*DEOXYGUA NOSINE

There total 35 articles about 5'-O-(4,4'-DIMETHOXYTRITYL)-2'-*DEOXYGUA NOSINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Diphenyl-carbamic acid 9-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2-propionylamino-9H-purin-6-yl ester (87036-65-5) → 5'-O-(p,p'-dimethoxytrityl)-2'-deoxyguanosine (81144-43-6)

Guidance literature:

With pyridine; ammonium hydroxide; for 10h; Ambient temperature;

DOI:10.1016/S0040-4039(00)88019-3

Reference yield: 98.0%

5'-O-dimethoxytrityl-N-isobutyryldeoxyguanosine (68892-41-1) → 5'-O-(p,p'-dimethoxytrityl)-2'-deoxyguanosine (81144-43-6)

Guidance literature:

With ammonium hydroxide; In 1,4-dioxane; for 72h;

DOI:10.1016/S0040-4039(00)77151-6

Reference yield: 97.0%

(E)-N′-(9-((2R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)-methyl)-4-hydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethylformimidamide → 5'-O-(p,p'-dimethoxytrityl)-2'-deoxyguanosine (81144-43-6)

Guidance literature:

With pyridine; ammonia; at 25 ℃; for 24h;

DOI:10.1021/ja973731g

upstream raw materials:

5'-O-dimethoxytrityl-N-isobutyryldeoxyguanosine

Diphenyl-carbamic acid 9-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2-propionylamino-9H-purin-6-yl ester

5'-O-(4,4'-dimethoxytrityl)-2-N-(diphenylacetyl)-2'-deoxyguanosine

N-(9-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-benzamide

Downstream raw materials:

2'-Deoxyguanosine

C₃₈H₃₇N₆O₁₀P

O6-Tse-5’-O-DMTr-2’-deoxyguanosine

C₅₇H₆₁N₅O₈Si