2-(2,6-dimethoxyphenyl)-3-trimethylsilylethynyl-8-bromo-1,10-phenanthroline

Base Information

Chemical Name:2-(2,6-dimethoxyphenyl)-3-trimethylsilylethynyl-8-bromo-1,10-phenanthroline
CAS No.:320573-12-4
Molecular Formula:C₂₅H₂₃BrN₂O₂Si
Molecular Weight:491.459
Hs Code.:

Synonyms:2-(2,6-dimethoxyphenyl)-3-trimethylsilylethynyl-8-bromo-1,10-phenanthroline

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Chemical Property of 2-(2,6-dimethoxyphenyl)-3-trimethylsilylethynyl-8-bromo-1,10-phenanthroline

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Technology Process of 2-(2,6-dimethoxyphenyl)-3-trimethylsilylethynyl-8-bromo-1,10-phenanthroline

There total 3 articles about 2-(2,6-dimethoxyphenyl)-3-trimethylsilylethynyl-8-bromo-1,10-phenanthroline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 320573-11-3
2-(2,6-dimethoxyphenyl)-3,8-dibromo-1,10-phenanthroline

: 1066-54-2
trimethylsilylacetylene

: 320573-12-4
2-(2,6-dimethoxyphenyl)-3-trimethylsilylethynyl-8-bromo-1,10-phenanthroline

Guidance literature:: With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In benzene; at 90 ℃; for 48h;
DOI:10.1021/ol006514k

Reference yield:

: 100125-12-0
3,8-dibromo-1,10-phenathroline

: 320573-12-4
2-(2,6-dimethoxyphenyl)-3-trimethylsilylethynyl-8-bromo-1,10-phenanthroline

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / diethyl ether; hexane / 5 h / 20 °C

1.2: diethyl ether; hexane / 20 °C

1.3: 50 percent / MnO₂ / CH₂Cl₂ / 1.5 h / 20 °C

2.1: 55 percent / Et₃N / PdCl₂(PPh₃)2; CuI / benzene / 48 h / 90 °C

With n-butyllithium; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In diethyl ether; hexane; benzene; 1.1: Metallation / 1.2: Substitution / 1.3: Oxidation / 2.1: Sonogashira coupling;
DOI:10.1021/ol006514k

Reference yield:

: 16932-45-9
1-bromo-2,6-dimethoxybenzene

: 320573-12-4
2-(2,6-dimethoxyphenyl)-3-trimethylsilylethynyl-8-bromo-1,10-phenanthroline

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / diethyl ether; hexane / 5 h / 20 °C

1.2: diethyl ether; hexane / 20 °C

1.3: 50 percent / MnO₂ / CH₂Cl₂ / 1.5 h / 20 °C

2.1: 55 percent / Et₃N / PdCl₂(PPh₃)2; CuI / benzene / 48 h / 90 °C

With n-butyllithium; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In diethyl ether; hexane; benzene; 1.1: Metallation / 1.2: Substitution / 1.3: Oxidation / 2.1: Sonogashira coupling;
DOI:10.1021/ol006514k