4-(4-bromophenyl)-1-(3-(trifluoromethyl)phenyl)-3,4,7,8-tetrahydroquinazoline-2,5(1H,6H)-dione

Base Information

Chemical Name:4-(4-bromophenyl)-1-(3-(trifluoromethyl)phenyl)-3,4,7,8-tetrahydroquinazoline-2,5(1H,6H)-dione
CAS No.:1625672-06-1
Molecular Formula:C₂₁H₁₆BrF₃N₂O₂
Molecular Weight:465.269
Hs Code.:

Synonyms:4-(4-bromophenyl)-1-(3-(trifluoromethyl)phenyl)-3,4,7,8-tetrahydroquinazoline-2,5(1H,6H)-dione

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Chemical Property of 4-(4-bromophenyl)-1-(3-(trifluoromethyl)phenyl)-3,4,7,8-tetrahydroquinazoline-2,5(1H,6H)-dione

Chemical Property:

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Technology Process of 4-(4-bromophenyl)-1-(3-(trifluoromethyl)phenyl)-3,4,7,8-tetrahydroquinazoline-2,5(1H,6H)-dione

There total 1 articles about 4-(4-bromophenyl)-1-(3-(trifluoromethyl)phenyl)-3,4,7,8-tetrahydroquinazoline-2,5(1H,6H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67280-72-2
1-bromo-4-(chloro(isocyanato)methyl)benzene

: 51924-57-3
3-[3-(trifluoromethyl)phenyl]aminocyclohex-2-en-1-one

: 1625672-06-1
4-(4-bromophenyl)-1-(3-(trifluoromethyl)phenyl)-3,4,7,8-tetrahydroquinazoline-2,5(1H,6H)-dione

Guidance literature:: In dichloromethane; Reflux;

Reference yield:

: 557-21-1
zinc(II) cyanide

: 1625672-06-1
4-(4-bromophenyl)-1-(3-(trifluoromethyl)phenyl)-3,4,7,8-tetrahydroquinazoline-2,5(1H,6H)-dione

: 1625675-73-1
4-(2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-1,2,3,4,5,6,7,8-octahydroquinazolin-4-yl)-benzonitrile

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 90 ℃; for 2h; Inert atmosphere;

Reference yield:

: 1625672-06-1
4-(4-bromophenyl)-1-(3-(trifluoromethyl)phenyl)-3,4,7,8-tetrahydroquinazoline-2,5(1H,6H)-dione

: 1625669-72-8
4-(3-(2-(1-methylpyrrolo[3,4-c]pyrazol-5(1H,4H,6H)-yl)-2-oxoethyl)-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-1,2,3,4,5,6,7,8-octahydroquinazolin-4-yl)benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 2 h / 90 °C / Inert atmosphere

2: lithium diisopropyl amide / N,N-dimethyl-formamide; acetonitrile; tetrahydrofuran / 0 - 10 °C / Cooling with ice

3: sodium hydroxide / water; 1,4-dioxane / 1 h / 20 °C

4: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; sodium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile;