methyl 2-{[4-(trifluoromethyl)-2-formylphenyl]amino}benzoate

Base Information

• Chemical Name: methyl 2-{[4-(trifluoromethyl)-2-formylphenyl]amino}benzoate
• CAS No.: 190845-27-3
• Molecular Formula: C₁₆H₁₂F₃NO₃
• Molecular Weight: 323.271
• Mol file: 190845-27-3.mol

Synonyms:methyl 2-{[4-(trifluoromethyl)-2-formylphenyl]amino}benzoate

Chemical Property of methyl 2-{[4-(trifluoromethyl)-2-formylphenyl]amino}benzoate

Chemical Property:

Purity/Quality:

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MSDS Files:

Useful:

Technology Process of methyl 2-{[4-(trifluoromethyl)-2-formylphenyl]amino}benzoate

There total 5 articles about methyl 2-{[4-(trifluoromethyl)-2-formylphenyl]amino}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

methyl 2-{[4-(trifluoromethyl)-2-(hydroxymethyl)phenyl]amino}benzoate (190845-26-2) → methyl 2-{[4-(trifluoromethyl)-2-formylphenyl]amino}benzoate (190845-27-3)

Guidance literature:

With manganese(IV) oxide; In acetone; for 18h; Heating;

DOI:10.1021/jm970004n

Reference yield:

o-iodo-methyl-benzoic acid (610-97-9) → methyl 2-{[4-(trifluoromethyl)-2-formylphenyl]amino}benzoate (190845-27-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 19 percent / CuI, Cu powder, N-ethylmorpholine / various solvent(s) / 48 h / 100 °C

2: tetrahydrofuran / 15 h / Ambient temperature

3: NaBH₄ / H₂O / 0.5 h

4: 85 percent / MnO₂ / acetone / 18 h / Heating

With N-ethylmorpholine;; manganese(IV) oxide; sodium tetrahydroborate; copper(l) iodide; copper; In tetrahydrofuran; water; acetone;

DOI:10.1021/jm970004n

Reference yield:

2-amino-5-(trifluoromethyl)benzoic acid (83265-53-6) → methyl 2-{[4-(trifluoromethyl)-2-formylphenyl]amino}benzoate (190845-27-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 19 percent / CuI, Cu powder, N-ethylmorpholine / various solvent(s) / 48 h / 100 °C

2: tetrahydrofuran / 15 h / Ambient temperature

3: NaBH₄ / H₂O / 0.5 h

4: 85 percent / MnO₂ / acetone / 18 h / Heating

With N-ethylmorpholine;; manganese(IV) oxide; sodium tetrahydroborate; copper(l) iodide; copper; In tetrahydrofuran; water; acetone;

DOI:10.1021/jm970004n

upstream raw materials:

methyl 2-{[4-(trifluoromethyl)-2-(hydroxymethyl)phenyl]amino}benzoate

o-iodo-methyl-benzoic acid

2-amino-5-(trifluoromethyl)benzoic acid

5-(trifluoromethyl)-2-{[2-(methoxycarbonyl)phenyl]amino}benzoic acid