5-(benzyl-methyl-amino)-2,2-difluoro-3-hydroxy-3-phenylpentanoic acid ethyl ester

Base Information

Chemical Name:5-(benzyl-methyl-amino)-2,2-difluoro-3-hydroxy-3-phenylpentanoic acid ethyl ester
CAS No.:651321-23-2
Molecular Formula:C₂₁H₂₅F₂NO₃
Molecular Weight:377.431
Hs Code.:

Synonyms:5-(benzyl-methyl-amino)-2,2-difluoro-3-hydroxy-3-phenylpentanoic acid ethyl ester

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Chemical Property of 5-(benzyl-methyl-amino)-2,2-difluoro-3-hydroxy-3-phenylpentanoic acid ethyl ester

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Technology Process of 5-(benzyl-methyl-amino)-2,2-difluoro-3-hydroxy-3-phenylpentanoic acid ethyl ester

There total 1 articles about 5-(benzyl-methyl-amino)-2,2-difluoro-3-hydroxy-3-phenylpentanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 667-27-6
Ethyl bromodifluoroacetate

: 21970-65-0
3-(benzyl-methyl-amino)-1-phenylpropan-1-one

: 651321-23-2
5-(benzyl-methyl-amino)-2,2-difluoro-3-hydroxy-3-phenylpentanoic acid ethyl ester

Guidance literature:: With samarium diiodide; In tetrahydrofuran; at 20 ℃; for 0.25h;
DOI:10.1016/j.bmc.2003.08.002

Reference yield: 95.0%

: 651321-23-2
5-(benzyl-methyl-amino)-2,2-difluoro-3-hydroxy-3-phenylpentanoic acid ethyl ester

: 651321-24-3
3,3-difluoro-4-hydroxy-1-methyl-4-phenylpiperidin-2-one

Guidance literature:: With hydrogen; palladium dihydroxide; In methanol; at 20 ℃; for 24h; under 760 Torr;
DOI:10.1016/j.bmc.2003.08.002

Reference yield:

: 651321-23-2
5-(benzyl-methyl-amino)-2,2-difluoro-3-hydroxy-3-phenylpentanoic acid ethyl ester

: 3,3-difluoro-4-hydroxy-1-methyl-4-phenylpiperidine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / H₂ / Pd(OH)2 / methanol / 24 h / 20 °C / 760 Torr

2: 65 percent / NaBH₄; TFA / dioxane / 24 h / Heating

With sodium tetrahydroborate; hydrogen; trifluoroacetic acid; palladium dihydroxide; In 1,4-dioxane; methanol;
DOI:10.1016/j.bmc.2003.08.002