benzyl 2-(benzyloxy)-4-(2-(N,4-dimethylphenylsulfonamido)-N-(4-(piperidin-4-yl)benzyl)acetamido)benzoate

Base Information

Chemical Name:benzyl 2-(benzyloxy)-4-(2-(N,4-dimethylphenylsulfonamido)-N-(4-(piperidin-4-yl)benzyl)acetamido)benzoate
CAS No.:1331747-82-0
Molecular Formula:C₄₃H₄₅N₃O₆S
Molecular Weight:731.913
Hs Code.:

Synonyms:benzyl 2-(benzyloxy)-4-(2-(N,4-dimethylphenylsulfonamido)-N-(4-(piperidin-4-yl)benzyl)acetamido)benzoate

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Chemical Property of benzyl 2-(benzyloxy)-4-(2-(N,4-dimethylphenylsulfonamido)-N-(4-(piperidin-4-yl)benzyl)acetamido)benzoate

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Technology Process of benzyl 2-(benzyloxy)-4-(2-(N,4-dimethylphenylsulfonamido)-N-(4-(piperidin-4-yl)benzyl)acetamido)benzoate

There total 10 articles about benzyl 2-(benzyloxy)-4-(2-(N,4-dimethylphenylsulfonamido)-N-(4-(piperidin-4-yl)benzyl)acetamido)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1331747-81-9
benzyl 2-(benzyloxy)-4-(2-(N,4-dimethylphenylsulfonamido)-N-(4-(1-(2,2,2-trifluoroacetyl)piperidin-4-yl)benzyl)acetamido)benzoate

: 1331747-82-0
benzyl 2-(benzyloxy)-4-(2-(N,4-dimethylphenylsulfonamido)-N-(4-(piperidin-4-yl)benzyl)acetamido)benzoate

Guidance literature:: With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 20 ℃; for 0.166667h; Inert atmosphere;
DOI:10.1002/cmdc.201100194

Reference yield:

: 1241832-99-4
benzyl 4-amino-2-(benzyloxy)benzoate

: 1331747-82-0
benzyl 2-(benzyloxy)-4-(2-(N,4-dimethylphenylsulfonamido)-N-(4-(piperidin-4-yl)benzyl)acetamido)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / methanol / 3 h / 45 °C / Molecular sieve; Inert atmosphere

1.2: 12 h / 20 °C / Inert atmosphere

2.1: dichlorotriphenylphosphorane / chloroform / 12 h / 60 °C / Inert atmosphere

3.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere

With lithium hydroxide monohydrate; water; acetic acid; dichlorotriphenylphosphorane; In tetrahydrofuran; methanol; chloroform;
DOI:10.1002/cmdc.201100194

Reference yield:

: 1331747-36-4
4-(1-(2,2,2-trifluoroacetyl)piperidin-4-yl)benzoyl chloride

: 1331747-82-0
benzyl 2-(benzyloxy)-4-(2-(N,4-dimethylphenylsulfonamido)-N-(4-(piperidin-4-yl)benzyl)acetamido)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine / ethyl acetate / 2 h / 20 °C

2.1: acetic acid / methanol / 3 h / 45 °C / Molecular sieve; Inert atmosphere

2.2: 12 h / 20 °C / Inert atmosphere

3.1: dichlorotriphenylphosphorane / chloroform / 12 h / 60 °C / Inert atmosphere

4.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere

With lithium hydroxide monohydrate; palladium 10% on activated carbon; water; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; dichlorotriphenylphosphorane; In tetrahydrofuran; methanol; chloroform; ethyl acetate; 1.1: Rosenmund reduction;
DOI:10.1002/cmdc.201100194