potassium isoquinolin-5-yltrifluoroborate

Base Information

• Chemical Name: potassium isoquinolin-5-yltrifluoroborate
• CAS No.: 1242733-92-1
• Molecular Formula: C₉H₆BF₃N*K
• Molecular Weight: 235.058
• Mol file: 1242733-92-1.mol

Synonyms:potassium isoquinolin-5-yltrifluoroborate

Chemical Property of potassium isoquinolin-5-yltrifluoroborate

Chemical Property:

Purity/Quality:

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Technology Process of potassium isoquinolin-5-yltrifluoroborate

There total 1 articles about potassium isoquinolin-5-yltrifluoroborate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

isoquinoline 5-boronic acid (371766-08-4) → potassium isoquinolin-5-yltrifluoroborate (1242733-92-1)

Guidance literature:

With potassium hydrogen difluoride; In methanol; water; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/ol101592r

Reference yield: 94.0%

tert-Butyl chloroacetate (107-59-5) + potassium isoquinolin-5-yltrifluoroborate (1242733-92-1) → isoquinolin-5-yl-acetic acid tert-butyl ester

Guidance literature:

With chloro(2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl’)]palladium(II); caesium carbonate; In tetrahydrofuran; water; at 100 ℃; for 18h; Inert atmosphere; Sealed tube;

DOI:10.1021/jo400488q

Reference yield: 39.0%

2,4-dimethylphenyl methanesulfonate (723755-74-6) + potassium isoquinolin-5-yltrifluoroborate (1242733-92-1) → 5-(2,4-dimethylphenyl)isoquinoline (1242470-64-9)

Guidance literature:

With bis(1,5-cyclooctadiene)nickel⁽⁰⁾; potassium phosphate; tricyclohexylphosphine tetrafluoroborate; In water; tert-butyl alcohol; at 110 ℃; for 4h; Inert atmosphere;

DOI:10.1021/ol101592r

upstream raw materials:

isoquinoline 5-boronic acid

Downstream raw materials:

5-(2,4-dimethylphenyl)isoquinoline