(1S,5R,7aS)-1-{(1S)-1-(hydroxymethyl)ethyl-2-[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]}-7a-methyl-4-phenylthio-2,3,5,6,7,7a-hexahydro-1H-inden-5-ol

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Chemical Name:(1S,5R,7aS)-1-{(1S)-1-(hydroxymethyl)ethyl-2-[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]}-7a-methyl-4-phenylthio-2,3,5,6,7,7a-hexahydro-1H-inden-5-ol
CAS No.:681180-39-2
Molecular Formula:C₂₆H₃₈O₄S
Molecular Weight:446.651
Hs Code.:

Synonyms:(1S,5R,7aS)-1-{(1S)-1-(hydroxymethyl)ethyl-2-[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]}-7a-methyl-4-phenylthio-2,3,5,6,7,7a-hexahydro-1H-inden-5-ol

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Chemical Property of (1S,5R,7aS)-1-{(1S)-1-(hydroxymethyl)ethyl-2-[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]}-7a-methyl-4-phenylthio-2,3,5,6,7,7a-hexahydro-1H-inden-5-ol

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Technology Process of (1S,5R,7aS)-1-{(1S)-1-(hydroxymethyl)ethyl-2-[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]}-7a-methyl-4-phenylthio-2,3,5,6,7,7a-hexahydro-1H-inden-5-ol

There total 8 articles about (1S,5R,7aS)-1-{(1S)-1-(hydroxymethyl)ethyl-2-[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]}-7a-methyl-4-phenylthio-2,3,5,6,7,7a-hexahydro-1H-inden-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 332950-58-0
S-tert-butyl (2S)-2-[(1S,5R,7aS)-5-hydroxy-7a-methyl-4-phenylthio-2,3,5,6,7,7a-hexahydro-1H-inden-1-yl]-3-[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]propanethioate

: 681180-39-2
(1S,5R,7aS)-1-{(1S)-1-(hydroxymethyl)ethyl-2-[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]}-7a-methyl-4-phenylthio-2,3,5,6,7,7a-hexahydro-1H-inden-5-ol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 3h; Heating;
DOI:10.1002/ejoc.200300611

Reference yield:

: 332950-54-6
S-tert-butyl 3-[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]propanethioate

: 681180-39-2
(1S,5R,7aS)-1-{(1S)-1-(hydroxymethyl)ethyl-2-[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]}-7a-methyl-4-phenylthio-2,3,5,6,7,7a-hexahydro-1H-inden-5-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 95 percent / LDA / tetrahydrofuran; hexane

2.1: TrSbCl₆ / CH₂Cl₂ / 2 h / -78 °C

2.2: 79 percent / KOH / methanol / 1 h / 20 °C

3.1: 66 percent / CeCl₃*7H₂O; NaBH₄ / methanol; tetrahydrofuran / 2 h / -78 °C

4.1: 100 percent / LiAlH₄ / tetrahydrofuran / 3 h / Heating

With sodium tetrahydroborate; lithium aluminium tetrahydride; cerium(III) chloride; lithium diisopropyl amide; triphenylmethylium hexachloroantimonate(V); In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1002/ejoc.200300611

Reference yield:

: (1E/Z)-1-(tert-butylthio)-3-[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]-1-(trimethylsilyloxy)prop-1-ene

: 681180-39-2
(1S,5R,7aS)-1-{(1S)-1-(hydroxymethyl)ethyl-2-[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]}-7a-methyl-4-phenylthio-2,3,5,6,7,7a-hexahydro-1H-inden-5-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: TrSbCl₆ / CH₂Cl₂ / 2 h / -78 °C

1.2: 79 percent / KOH / methanol / 1 h / 20 °C

2.1: 66 percent / CeCl₃*7H₂O; NaBH₄ / methanol; tetrahydrofuran / 2 h / -78 °C

3.1: 100 percent / LiAlH₄ / tetrahydrofuran / 3 h / Heating

With sodium tetrahydroborate; lithium aluminium tetrahydride; cerium(III) chloride; triphenylmethylium hexachloroantimonate(V); In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1002/ejoc.200300611