C₂₂H₂₁ClF₃N₃O₂

Base Information

Chemical Name:C₂₂H₂₁ClF₃N₃O₂
CAS No.:1372540-34-5
Molecular Formula:C₂₂H₂₁ClF₃N₃O₂
Molecular Weight:451.876
Hs Code.:

C<sub>22</sub>H<sub>21</sub>ClF<sub>3</sub>N<sub>3</sub>O<sub>2</sub>

Synonyms:C₂₂H₂₁ClF₃N₃O₂

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₂₂H₂₁ClF₃N₃O₂

Chemical Property:

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Technology Process of C₂₂H₂₁ClF₃N₃O₂

There total 7 articles about C₂₂H₂₁ClF₃N₃O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1372540-25-4
2-methyl-1-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-6-(morpholin-4-yl)-1H-1,3-benzodiazole-4-carboxylic acid

: 1372540-34-5
C₂₂H₂₁ClF₃N₃O₂

Guidance literature:: With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 0.166667h; Product distribution / selectivity;

Reference yield:

: 2516-95-2
5-chloro-2-nitrobenzoic acid

: 1372540-34-5
C₂₂H₂₁ClF₃N₃O₂

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium tert-butylate; N-methoxylamine hydrochloride / copper diacetate / N,N-dimethyl-formamide / 3 h / 0 °C / Inert atmosphere

1.2: pH 1

2.1: triethylamine; HATU / tetrahydrofuran / 3 h / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 110 °C

4.1: iron / 5 h / Reflux

5.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

6.1: water; lithium hydroxide / tetrahydrofuran / 1 h / 50 °C

6.2: pH 3 / Acidic conditions

7.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.17 h / 20 °C

With oxalyl dichloride; potassium tert-butylate; water; N-methoxylamine hydrochloride; iron; potassium carbonate; triethylamine; HATU; lithium hydroxide; copper diacetate; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 193481-78-6
3-Amino-5-chloro-2-nitrobenzoic acid

: 1372540-34-5
C₂₂H₂₁ClF₃N₃O₂

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine; HATU / tetrahydrofuran / 3 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 110 °C

3.1: iron / 5 h / Reflux

4.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

5.1: water; lithium hydroxide / tetrahydrofuran / 1 h / 50 °C

5.2: pH 3 / Acidic conditions

6.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.17 h / 20 °C

With oxalyl dichloride; water; iron; potassium carbonate; triethylamine; HATU; lithium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;