3-(2,5-difluoro-phenyl)-2-(3-isopropyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-3-oxo-propionaldehyde

Base Information

Chemical Name:3-(2,5-difluoro-phenyl)-2-(3-isopropyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-3-oxo-propionaldehyde
CAS No.:908837-16-1
Molecular Formula:C₁₈H₁₅F₂N₃O₂
Molecular Weight:343.333
Hs Code.:

3-(2,5-difluoro-phenyl)-2-(3-isopropyl-[1,2,4]triazolo[4,3-<i>a</i>]pyridin-6-yl)-3-oxo-propionaldehyde

Synonyms:3-(2,5-difluoro-phenyl)-2-(3-isopropyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-3-oxo-propionaldehyde

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Chemical Property of 3-(2,5-difluoro-phenyl)-2-(3-isopropyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-3-oxo-propionaldehyde

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Technology Process of 3-(2,5-difluoro-phenyl)-2-(3-isopropyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-3-oxo-propionaldehyde

There total 3 articles about 3-(2,5-difluoro-phenyl)-2-(3-isopropyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-3-oxo-propionaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 908837-12-7
1-(2,5-difluoro-phenyl)-2-(3-isopropyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-ethanone

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 908837-16-1
3-(2,5-difluoro-phenyl)-2-(3-isopropyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-3-oxo-propionaldehyde

Guidance literature:: at 90 ℃; for 1h;
DOI:10.1016/j.bmcl.2006.05.056

Reference yield:

: 459448-04-5
3-isopropyl-[1,2,4]triazolo[4,3-a]-6-pyridinecarboxaldehyde

: 908837-16-1
3-(2,5-difluoro-phenyl)-2-(3-isopropyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-3-oxo-propionaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: 39 percent / t-BuOK / tetrahydrofuran; propan-2-ol / 0.75 h / 23 °C

2: 100 percent / 1 h / 90 °C

With potassium tert-butylate; In tetrahydrofuran; isopropyl alcohol;
DOI:10.1016/j.bmcl.2006.05.056

Reference yield:

: [(2,5-difluoro-phenyl)-phenylamino-methyl]-phosphonic acid diphenyl ester

: 908837-16-1
3-(2,5-difluoro-phenyl)-2-(3-isopropyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-3-oxo-propionaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: 39 percent / t-BuOK / tetrahydrofuran; propan-2-ol / 0.75 h / 23 °C

2: 100 percent / 1 h / 90 °C

With potassium tert-butylate; In tetrahydrofuran; isopropyl alcohol;
DOI:10.1016/j.bmcl.2006.05.056