Technology Process of (3aβ,12β,12aβ,12bβ)-9-(benzyloxy)-1,2,3,3a,4,5,11,12,12a,12b-decahydro-3aβ-ethyl-5-oxoisoquino<2,1,8-lma>carbazole-12-carboxylic acid 2-<2-(1-pyrrolidinyl)ethyl>hydrazide
There total 6 articles about (3aβ,12β,12aβ,12bβ)-9-(benzyloxy)-1,2,3,3a,4,5,11,12,12a,12b-decahydro-3aβ-ethyl-5-oxoisoquino<2,1,8-lma>carbazole-12-carboxylic acid 2-<2-(1-pyrrolidinyl)ethyl>hydrazide which
guide to synthetic route it.
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synthetic route:
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103581-37-9
(3aβ,12β,12aβ,12bβ)-1,2,3,3a,4,5,11,12,12a,12b-decahydro-9-(benzyloxy)-3aβ-ethyl-5-oxoisoquino<2,1,8-lma>carbazole-12-carboxylic acid
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103558-75-4
(3aβ,12β,12aβ,12bβ)-9-(benzyloxy)-1,2,3,3a,4,5,11,12,12a,12b-decahydro-3aβ-ethyl-5-oxoisoquino<2,1,8-lma>carbazole-12-carboxylic acid 2-<2-(1-pyrrolidinyl)ethyl>hydrazide
- Guidance literature:
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With
diethyl cyanophosphonate; triethylamine;
In
N,N-dimethyl-formamide;
for 0.5h;
Ambient temperature;
DOI:10.1021/jm00083a004
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103558-75-4
(3aβ,12β,12aβ,12bβ)-9-(benzyloxy)-1,2,3,3a,4,5,11,12,12a,12b-decahydro-3aβ-ethyl-5-oxoisoquino<2,1,8-lma>carbazole-12-carboxylic acid 2-<2-(1-pyrrolidinyl)ethyl>hydrazide
- Guidance literature:
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Multi-step reaction with 5 steps
1: 75.1 percent / toluene / 20 h / Heating
2: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, 0.5 h
3: 2.) 15percent ethanol. HCl / 1.) mesitylene, reflux, 12 h, 2.) mesitylene, reflux, 0.5 h
4: 65.4 percent / tetrakis(triphenylphosphine)palladium(0), Ph3P, 2-ethylhexanoic acid / ethyl acetate; CHCl3 / 8 h / Ambient temperature
5: 66.3 percent / diethyl cyanophosphonate (DEPC), Et3N / dimethylformamide / 0.5 h / Ambient temperature
With
hydrogenchloride; tetrakis(triphenylphosphine) palladium(0); 2-Ethylhexanoic acid; diethyl cyanophosphonate; sodium hydride; triethylamine; triphenylphosphine;
In
chloroform; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00083a004
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103558-75-4
(3aβ,12β,12aβ,12bβ)-9-(benzyloxy)-1,2,3,3a,4,5,11,12,12a,12b-decahydro-3aβ-ethyl-5-oxoisoquino<2,1,8-lma>carbazole-12-carboxylic acid 2-<2-(1-pyrrolidinyl)ethyl>hydrazide
- Guidance literature:
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Multi-step reaction with 4 steps
1: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, 0.5 h
2: 2.) 15percent ethanol. HCl / 1.) mesitylene, reflux, 12 h, 2.) mesitylene, reflux, 0.5 h
3: 65.4 percent / tetrakis(triphenylphosphine)palladium(0), Ph3P, 2-ethylhexanoic acid / ethyl acetate; CHCl3 / 8 h / Ambient temperature
4: 66.3 percent / diethyl cyanophosphonate (DEPC), Et3N / dimethylformamide / 0.5 h / Ambient temperature
With
hydrogenchloride; tetrakis(triphenylphosphine) palladium(0); 2-Ethylhexanoic acid; diethyl cyanophosphonate; sodium hydride; triethylamine; triphenylphosphine;
In
chloroform; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00083a004
