2-[5-chloro-2-(1-ethyl-5,5-dimethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-7-ylamino)-pyrimidin-4-ylamino]-3-fluoro-N-methyl-benzamide

Base Information

Chemical Name:2-[5-chloro-2-(1-ethyl-5,5-dimethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-7-ylamino)-pyrimidin-4-ylamino]-3-fluoro-N-methyl-benzamide
CAS No.:1022971-71-6
Molecular Formula:C₂₆H₂₈ClFN₆O₂
Molecular Weight:510.999
Hs Code.:

Synonyms:2-[5-chloro-2-(1-ethyl-5,5-dimethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-7-ylamino)-pyrimidin-4-ylamino]-3-fluoro-N-methyl-benzamide

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Chemical Property of 2-[5-chloro-2-(1-ethyl-5,5-dimethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-7-ylamino)-pyrimidin-4-ylamino]-3-fluoro-N-methyl-benzamide

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Technology Process of 2-[5-chloro-2-(1-ethyl-5,5-dimethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-7-ylamino)-pyrimidin-4-ylamino]-3-fluoro-N-methyl-benzamide

There total 8 articles about 2-[5-chloro-2-(1-ethyl-5,5-dimethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-7-ylamino)-pyrimidin-4-ylamino]-3-fluoro-N-methyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 959246-74-3
2-(2,5-dichloro-pyrimidin-4-ylamino)-3-fluoro-N-methyl-benzamide

: 1022971-65-8
7-amino-1-ethyl-5,5-dimethyl-1,3,4,5-tetrahydro-benzo[b]azepin-2-one

: 1022971-71-6
2-[5-chloro-2-(1-ethyl-5,5-dimethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-7-ylamino)-pyrimidin-4-ylamino]-3-fluoro-N-methyl-benzamide

Guidance literature:: With camphor-10-sulfonic acid; In isopropyl alcohol; at 120 ℃; for 0.5h; Microwave irradiation;
DOI:10.1016/j.bmcl.2010.11.045

Reference yield:

: 221692-43-9
5,5-dimethyl-1,3,4,5-tetrahydro-benzo[b]azepin-2-one

: 1022971-71-6
2-[5-chloro-2-(1-ethyl-5,5-dimethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-7-ylamino)-pyrimidin-4-ylamino]-3-fluoro-N-methyl-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid; nitric acid / 0.17 h / 0 °C

2: caesium carbonate / N,N-dimethyl-formamide / 2.5 h / 20 °C

3: 10% palladium on activated carbon; hydrazine hydrate / ethanol / 24 h / 60 °C

4: camphor-10-sulfonic acid / isopropyl alcohol / 0.5 h / 120 °C / Microwave irradiation

With sulfuric acid; 10% palladium on activated carbon; camphor-10-sulfonic acid; nitric acid; caesium carbonate; hydrazine hydrate; In ethanol; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1016/j.bmcl.2010.11.045

Reference yield:

: 1017789-26-2
2-amino-3-fluoro-N-methyl-benzamide

: 1022971-71-6
2-[5-chloro-2-(1-ethyl-5,5-dimethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-7-ylamino)-pyrimidin-4-ylamino]-3-fluoro-N-methyl-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 21 h / 100 °C

2: camphor-10-sulfonic acid / isopropyl alcohol / 0.5 h / 120 °C / Microwave irradiation

With camphor-10-sulfonic acid; N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; isopropyl alcohol;
DOI:10.1016/j.bmcl.2010.11.045