{(S)-2,2-dimethyl-1-[N'-(4-thiazol-2-ylbenzyl)hydrazinocarbonyl]propyl}carbamic acid methyl ester

Base Information

• Chemical Name: {(S)-2,2-dimethyl-1-[N'-(4-thiazol-2-ylbenzyl)hydrazinocarbonyl]propyl}carbamic acid methyl ester
• CAS No.: 1010702-53-0
• Molecular Formula: C₁₈H₂₄N₄O₃S
• Molecular Weight: 376.48
• Mol file: 1010702-53-0.mol

Synonyms:{(S)-2,2-dimethyl-1-[N'-(4-thiazol-2-ylbenzyl)hydrazinocarbonyl]propyl}carbamic acid methyl ester

Chemical Property of {(S)-2,2-dimethyl-1-[N'-(4-thiazol-2-ylbenzyl)hydrazinocarbonyl]propyl}carbamic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {(S)-2,2-dimethyl-1-[N'-(4-thiazol-2-ylbenzyl)hydrazinocarbonyl]propyl}carbamic acid methyl ester

There total 1 articles about {(S)-2,2-dimethyl-1-[N'-(4-thiazol-2-ylbenzyl)hydrazinocarbonyl]propyl}carbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

4-(thiazol-2-yl)-benzaldehyde (198904-53-9) + methyl (S)-(1-hydrazinyl-3,3-dimethyl-1-oxobutan-2-yl)carbamate (198904-78-8) → {(S)-2,2-dimethyl-1-[N'-(4-thiazol-2-ylbenzyl)hydrazinocarbonyl]propyl}carbamic acid methyl ester (1010702-53-0)

Guidance literature:

4-(thiazol-2-yl)-benzaldehyde; methyl (S)-(1-hydrazinyl-3,3-dimethyl-1-oxobutan-2-yl)carbamate; With toluene-4-sulfonic acid; In tetrahydrofuran; at 20 ℃; for 1h;

With sodium cyanoborohydride; In tetrahydrofuran; at 20 ℃; Further stages.;

DOI:10.1021/jm070680h

Reference yield: 42.0%

{(S)-2,2-dimethyl-1-[N'-(4-thiazol-2-ylbenzyl)hydrazinocarbonyl]propyl}carbamic acid methyl ester (1010702-53-0) + C29H46N2O4Si → methyl ((S)-1-(2-((R)-5-(((S)-1-(allylamino)-3-methyl-1-oxobutan-2-yl)amino)-4-(4-allylbenzyl)-4-((tert-butyldimethylsilyl)oxy)-5-oxopentyl)-2-(4-(thiazol-2-yl)benzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

Guidance literature:

C₂₉H₄₆N₂O₄Si; With acetic acid; at 20 ℃; Inert atmosphere; Molecular sieve;

{(S)-2,2-dimethyl-1-[N'-(4-thiazol-2-ylbenzyl)hydrazinocarbonyl]propyl}carbamic acid methyl ester; at 20 ℃; Molecular sieve; Inert atmosphere;

With sodium tris(acetoxy)borohydride; at 20 ℃; for 18h; Molecular sieve; Inert atmosphere;

DOI:10.1021/jm500434q

Reference yield:

{(S)-2,2-dimethyl-1-[N'-(4-thiazol-2-ylbenzyl)hydrazinocarbonyl]propyl}carbamic acid methyl ester (1010702-53-0) + C33H51NO4Si2 → C51H75N5O6SSi2

Guidance literature:

{(S)-2,2-dimethyl-1-[N'-(4-thiazol-2-ylbenzyl)hydrazinocarbonyl]propyl}carbamic acid methyl ester; C₃₃H₅₁NO₄Si₂; With acetic acid; In tetrahydrofuran; at 20 ℃; for 0.25h;

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; at 20 ℃; Further stages.;

DOI:10.1021/jm070680h

upstream raw materials:

4-(thiazol-2-yl)-benzaldehyde

methyl (S)-(1-hydrazinyl-3,3-dimethyl-1-oxobutan-2-yl)carbamate