(2R)-N-[[(4R)-4-cyclopropyl-2,5-dioxo-imidazolidin-4-yl]methyl]-2-[[4-(trifluoromethyl)phenyl]methyl]butanamide

Base Information

Chemical Name:(2R)-N-[[(4R)-4-cyclopropyl-2,5-dioxo-imidazolidin-4-yl]methyl]-2-[[4-(trifluoromethyl)phenyl]methyl]butanamide
CAS No.:1607004-33-0
Molecular Formula:C₁₉H₂₂F₃N₃O₃
Molecular Weight:397.397
Hs Code.:

Synonyms:(2R)-N-[[(4R)-4-cyclopropyl-2,5-dioxo-imidazolidin-4-yl]methyl]-2-[[4-(trifluoromethyl)phenyl]methyl]butanamide

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Chemical Property of (2R)-N-[[(4R)-4-cyclopropyl-2,5-dioxo-imidazolidin-4-yl]methyl]-2-[[4-(trifluoromethyl)phenyl]methyl]butanamide

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Technology Process of (2R)-N-[[(4R)-4-cyclopropyl-2,5-dioxo-imidazolidin-4-yl]methyl]-2-[[4-(trifluoromethyl)phenyl]methyl]butanamide

There total 2 articles about (2R)-N-[[(4R)-4-cyclopropyl-2,5-dioxo-imidazolidin-4-yl]methyl]-2-[[4-(trifluoromethyl)phenyl]methyl]butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1607004-49-8
(2R)-2-[[4-(trifluoromethyl)phenyl]methyl]butanoic acid

: (5R)-5-(aminomethyl)-5-cyclopropyl-imidazolidine-2,4-dione hydrochloride

: 1607004-33-0
(2R)-N-[[(4R)-4-cyclopropyl-2,5-dioxo-imidazolidin-4-yl]methyl]-2-[[4-(trifluoromethyl)phenyl]methyl]butanamide

Guidance literature:: (2R)-2-[[4-(trifluoromethyl)phenyl]methyl]butanoic acid; With N,N-dimethyl-ethanamine; HATU; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Inert atmosphere;

(5R)-5-(aminomethyl)-5-cyclopropyl-imidazolidine-2,4-dione hydrochloride; for 2.5h;

Reference yield:

: 1607004-48-7
(4S)-4-benzyl-3-[(2R)-2-[[4-(trifluoromethyl)phenyl]methyl]butanoyl] oxazolidin-2-one

: 1607004-33-0
(2R)-N-[[(4R)-4-cyclopropyl-2,5-dioxo-imidazolidin-4-yl]methyl]-2-[[4-(trifluoromethyl)phenyl]methyl]butanamide

Guidance literature:: Multi-step reaction with 2 steps

1: dihydrogen peroxide; lithium hydroxide / tetrahydrofuran; water / 2 h / 0 °C

2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere

With dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.7b00650