5-(4-methoxy-phenyl)-N³-(tetrahydro-furan-2-ylmethyl)-pyrazine-2,3-diamine

Base Information

• Chemical Name: 5-(4-methoxy-phenyl)-N³-(tetrahydro-furan-2-ylmethyl)-pyrazine-2,3-diamine
• CAS No.: 917565-40-3
• Molecular Formula: C₁₆H₂₀N₄O₂
• Molecular Weight: 300.36
• Mol file: 917565-40-3.mol

Synonyms:5-(4-methoxy-phenyl)-N³-(tetrahydro-furan-2-ylmethyl)-pyrazine-2,3-diamine

Chemical Property of 5-(4-methoxy-phenyl)-N³-(tetrahydro-furan-2-ylmethyl)-pyrazine-2,3-diamine

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 5-(4-methoxy-phenyl)-N³-(tetrahydro-furan-2-ylmethyl)-pyrazine-2,3-diamine

There total 2 articles about 5-(4-methoxy-phenyl)-N³-(tetrahydro-furan-2-ylmethyl)-pyrazine-2,3-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C7H9BO2 + 5-bromo-N3-(tetrahydro-furan-2-ylmethyl)-pyrazine-2,3-diamine (917565-45-8) → 5-(4-methoxy-phenyl)-N3-(tetrahydro-furan-2-ylmethyl)-pyrazine-2,3-diamine (917565-40-3)

Guidance literature:

With sodium carbonate; 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; In ethanol; toluene; at 90 ℃; for 24h;

DOI:10.1016/j.tetlet.2006.09.097

Reference yield:

TETRAHYDROFURFURYLAMINE (4795-29-3) → 5-(4-methoxy-phenyl)-N3-(tetrahydro-furan-2-ylmethyl)-pyrazine-2,3-diamine (917565-40-3)

Guidance literature:

Multi-step reaction with 2 steps

1: DIPEA / ethanol / 0.58 h / 140 °C / microwave irradiation

2: Na₂CO₃ / Pd(dppf)2Cl₂*DCM / toluene; ethanol / 24 h / 90 °C

With sodium carbonate; N-ethyl-N,N-diisopropylamine; 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; In ethanol; toluene; 2: Suzuki reaction;

DOI:10.1016/j.tetlet.2006.09.097

Reference yield: 84.0%

5-(4-methoxy-phenyl)-N3-(tetrahydro-furan-2-ylmethyl)-pyrazine-2,3-diamine (917565-40-3) → 6-(4-methoxy-phenyl)-1-(tetrahydro-furan-2-ylmethyl)-1,3-dihydro-[1,2,5]thiadiazolo[3,4-b]pyrazine 2,2-dioxide

Guidance literature:

With SULFAMIDE; In pyridine; at 160 ℃; for 0.25h; microwave irradiation;

DOI:10.1016/j.tetlet.2006.09.097

upstream raw materials:

5-bromo-N³-(tetrahydro-furan-2-ylmethyl)-pyrazine-2,3-diamine

TETRAHYDROFURFURYLAMINE