(R)-1-(4-methoxybenzyl)-7-methylene-4,5,6,7-tetrahydro-1H-benzo[d] [1,2,3] triazol-4-ol

Base Information

Chemical Name:(R)-1-(4-methoxybenzyl)-7-methylene-4,5,6,7-tetrahydro-1H-benzo[d] [1,2,3] triazol-4-ol
CAS No.:1585257-62-0
Molecular Formula:C₁₅H₁₇N₃O₂
Molecular Weight:271.319
Hs Code.:

Synonyms:(R)-1-(4-methoxybenzyl)-7-methylene-4,5,6,7-tetrahydro-1H-benzo[d] [1,2,3] triazol-4-ol

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Chemical Property of (R)-1-(4-methoxybenzyl)-7-methylene-4,5,6,7-tetrahydro-1H-benzo[d] [1,2,3] triazol-4-ol

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Technology Process of (R)-1-(4-methoxybenzyl)-7-methylene-4,5,6,7-tetrahydro-1H-benzo[d] [1,2,3] triazol-4-ol

There total 4 articles about (R)-1-(4-methoxybenzyl)-7-methylene-4,5,6,7-tetrahydro-1H-benzo[d] [1,2,3] triazol-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₁H₃₂IN₃O₂Si

: 1585257-62-0
(R)-1-(4-methoxybenzyl)-7-methylene-4,5,6,7-tetrahydro-1H-benzo[d] [1,2,3] triazol-4-ol

Guidance literature:: Multi-step reaction with 2 steps

1: palladium diacetate; tetrabutylammomium bromide; tetrabutylammonium acetate / neat (no solvent) / 2 h / 100 °C / Inert atmosphere

2: pyridine hydrogenfluoride / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

With tetrabutylammomium bromide; tetrabutylammonium acetate; palladium diacetate; pyridine hydrogenfluoride; In tetrahydrofuran; 1: |Heck Reaction;
DOI:10.1021/acschembio.5b00755

Reference yield:

: 1585257-61-9
(R)-tert-butyl((1-iodohept-6-en-1-yn-3-yl)oxy)dimethylsilane

: 1585257-62-0
(R)-1-(4-methoxybenzyl)-7-methylene-4,5,6,7-tetrahydro-1H-benzo[d] [1,2,3] triazol-4-ol

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide / tetrahydrofuran / 20 °C / Inert atmosphere

2: palladium diacetate; tetrabutylammomium bromide; tetrabutylammonium acetate / neat (no solvent) / 2 h / 100 °C / Inert atmosphere

3: pyridine hydrogenfluoride / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

With copper(l) iodide; tetrabutylammomium bromide; tetrabutylammonium acetate; palladium diacetate; pyridine hydrogenfluoride; In tetrahydrofuran; 1: |Huisgen Cycloaddition / 2: |Heck Reaction;
DOI:10.1021/acschembio.5b00755

Reference yield:

: C₁₃H₂₄OSi

: 1585257-62-0
(R)-1-(4-methoxybenzyl)-7-methylene-4,5,6,7-tetrahydro-1H-benzo[d] [1,2,3] triazol-4-ol

Guidance literature:: Multi-step reaction with 4 steps

1: copper(l) iodide; N-iodomorpholine-hydrogen iodide / tetrahydrofuran / 18 h / 20 °C / Inert atmosphere

2: copper(l) iodide / tetrahydrofuran / 20 °C / Inert atmosphere

3: palladium diacetate; tetrabutylammomium bromide; tetrabutylammonium acetate / neat (no solvent) / 2 h / 100 °C / Inert atmosphere

4: pyridine hydrogenfluoride / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

With copper(l) iodide; tetrabutylammomium bromide; tetrabutylammonium acetate; palladium diacetate; N-iodomorpholine-hydrogen iodide; pyridine hydrogenfluoride; In tetrahydrofuran; 2: |Huisgen Cycloaddition / 3: |Heck Reaction;
DOI:10.1021/acschembio.5b00755