C₁₄H₂₀FNO₂S

Base Information

• Chemical Name: C₁₄H₂₀FNO₂S
• CAS No.: 1361409-32-6
• Molecular Formula: C₁₄H₂₀FNO₂S
• Molecular Weight: 285.383
• Mol file: 1361409-32-6.mol

Synonyms:C₁₄H₂₀FNO₂S

Chemical Property of C₁₄H₂₀FNO₂S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₄H₂₀FNO₂S

There total 1 articles about C₁₄H₂₀FNO₂S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

3-(3-fluoropropoxy)benzaldehyde (467458-97-5) + S-tert-butylsulfinimide (146374-27-8) → C14H20FNO2S (1361409-32-6)

Guidance literature:

With titanium(IV) tetraethanolate; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2012.01.079

Reference yield: 97.0%

C14H20FNO2S (1361409-32-6) + 1-bromo-4-(difluoromethoxy)benzene (5905-69-1) → C21H26F3NO3S (1361409-35-9)

Guidance literature:

C₁₄H₂₀FNO₂S; With n-butyllithium; isopropylmagnesium bromide; In tetrahydrofuran; hexane; at 0 ℃;

1-bromo-4-(difluoromethoxy)benzene; In tetrahydrofuran; hexane; at -65 ℃;

DOI:10.1016/j.bmcl.2012.01.079

Reference yield:

C14H20FNO2S (1361409-32-6) → C22H21F5N4O2 (1361409-30-4)

Guidance literature:

Multi-step reaction with 6 steps

1.1: n-butyllithium; isopropylmagnesium bromide / tetrahydrofuran; hexane / 0 °C

1.2: -65 °C

2.1: hydrogenchloride / methanol; diethyl ether / 12 h

3.1: sodium carbonate / dichloromethane / 0 °C

4.1: potassium tert-butylate / tetrahydrofuran / -78 °C

5.1: N-ethyl-N,N-diisopropylamine / ethanol / 70 °C

6.1: tert.-butylhydroperoxide; ammonium hydroxide / methanol / 12 h

With hydrogenchloride; tert.-butylhydroperoxide; ammonium hydroxide; n-butyllithium; potassium tert-butylate; isopropylmagnesium bromide; sodium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; dichloromethane;

DOI:10.1016/j.bmcl.2012.01.079

upstream raw materials:

3-(3-fluoropropoxy)benzaldehyde

S-tert-butylsulfinimide

Downstream raw materials:

C₂₂H₂₁F₅N₄O₂

C₁₇H₁₈F₃NO₂

C₁₈H₁₆F₃NO₂S

C₁₉H₁₆F₃NO₂S₃