N-{[4-(3,5-difluorobenzenesulfonyl)phenyl]methyl}imidazo[1,2-a]pyrimidine-6-carboxamide

Base Information

Chemical Name:N-{[4-(3,5-difluorobenzenesulfonyl)phenyl]methyl}imidazo[1,2-a]pyrimidine-6-carboxamide
CAS No.:1362148-79-5
Molecular Formula:C₂₀H₁₄F₂N₄O₃S
Molecular Weight:428.419
Hs Code.:

Synonyms:N-{[4-(3,5-difluorobenzenesulfonyl)phenyl]methyl}imidazo[1,2-a]pyrimidine-6-carboxamide

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Chemical Property of N-{[4-(3,5-difluorobenzenesulfonyl)phenyl]methyl}imidazo[1,2-a]pyrimidine-6-carboxamide

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Technology Process of N-{[4-(3,5-difluorobenzenesulfonyl)phenyl]methyl}imidazo[1,2-a]pyrimidine-6-carboxamide

There total 4 articles about N-{[4-(3,5-difluorobenzenesulfonyl)phenyl]methyl}imidazo[1,2-a]pyrimidine-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 944896-64-4
imidazo [1,2-a]pyrimidine-6-carboxylic acid

: 1448536-61-5
(4-((3,5-difluorophenyl)sulfonyl)phenyl)methanamine

: 1362148-79-5
N-{[4-(3,5-difluorobenzenesulfonyl)phenyl]methyl}imidazo[1,2-a]pyrimidine-6-carboxamide

Guidance literature:: imidazo [1,2-a]pyrimidine-6-carboxylic acid; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 25 ℃; for 0.416667h;

(4-((3,5-difluorophenyl)sulfonyl)phenyl)methanamine; In N,N-dimethyl-formamide; at 25 ℃; for 16h;
DOI:10.1021/jm4008664

Reference yield:

: 1448536-58-0
N-(4-(3,5-difluorophenylsulfonyl)benzyl)acetamide

: 1362148-79-5
N-{[4-(3,5-difluorobenzenesulfonyl)phenyl]methyl}imidazo[1,2-a]pyrimidine-6-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / isopropyl alcohol / 100 °C

2.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.42 h / 25 °C

2.2: 16 h / 25 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jm4008664

Reference yield:

: 156545-07-2
3,5-difluorophenylboronic acid

: 1362148-79-5
N-{[4-(3,5-difluorobenzenesulfonyl)phenyl]methyl}imidazo[1,2-a]pyrimidine-6-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper diacetate; potassium carbonate / dimethyl sulfoxide / 25 °C / Molecular sieve

2.1: hydrogenchloride / isopropyl alcohol / 100 °C

3.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.42 h / 25 °C

3.2: 16 h / 25 °C

With hydrogenchloride; copper diacetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jm4008664