(4S,4aS,5aR,12aS)-8-amino-13-(dimethylamino)-9-[ (dimethylamino)methyl]-4a-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-10-fluoro-11a,12,12a,13-tetrahydro-5-hydroxy-3,7-bis(phenylmethoxy)-naphthaceno[2,3-d]isoxazole-4,6(4aH,11H)-dione

Base Information

• Chemical Name: (4S,4aS,5aR,12aS)-8-amino-13-(dimethylamino)-9-[ (dimethylamino)methyl]-4a-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-10-fluoro-11a,12,12a,13-tetrahydro-5-hydroxy-3,7-bis(phenylmethoxy)-naphthaceno[2,3-d]isoxazole-4,6(4aH,11H)-dione
• CAS No.: 1207284-92-1
• Molecular Formula: C₄₁H₄₆FN₃O₇Si
• Molecular Weight: 739.916
• Mol file: 1207284-92-1.mol

Synonyms:(4S,4aS,5aR,12aS)-8-amino-13-(dimethylamino)-9-[ (dimethylamino)methyl]-4a-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-10-fluoro-11a,12,12a,13-tetrahydro-5-hydroxy-3,7-bis(phenylmethoxy)-naphthaceno[2,3-d]isoxazole-4,6(4aH,11H)-dione

Chemical Property of (4S,4aS,5aR,12aS)-8-amino-13-(dimethylamino)-9-[ (dimethylamino)methyl]-4a-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-10-fluoro-11a,12,12a,13-tetrahydro-5-hydroxy-3,7-bis(phenylmethoxy)-naphthaceno[2,3-d]isoxazole-4,6(4aH,11H)-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4S,4aS,5aR,12aS)-8-amino-13-(dimethylamino)-9-[ (dimethylamino)methyl]-4a-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-10-fluoro-11a,12,12a,13-tetrahydro-5-hydroxy-3,7-bis(phenylmethoxy)-naphthaceno[2,3-d]isoxazole-4,6(4aH,11H)-dione

There total 1 articles about (4S,4aS,5aR,12aS)-8-amino-13-(dimethylamino)-9-[ (dimethylamino)methyl]-4a-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-10-fluoro-11a,12,12a,13-tetrahydro-5-hydroxy-3,7-bis(phenylmethoxy)-naphthaceno[2,3-d]isoxazole-4,6(4aH,11H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

(4S,4aS,5aR,12aS)-13-(dimethylamino)-4a-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-8-(di-2-propen-1-ylamino)-10-fluoro-11a,12,12a,13-tetrahydro-5-hydroxy-3,7-bis(phenylmethoxy)-naphthaceno[2,3-d]isoxazole-4,6(4aH,11H)-dione (1207284-91-0) → (4S,4aS,5aR,12aS)-8-amino-13-(dimethylamino)-9-[ (dimethylamino)methyl]-4a-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-10-fluoro-11a,12,12a,13-tetrahydro-5-hydroxy-3,7-bis(phenylmethoxy)-naphthaceno[2,3-d]isoxazole-4,6(4aH,11H)-dione (1207284-92-1)

Guidance literature:

With 1,3-dimethylbarbituric acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; at 35 ℃; for 4h; Inert atmosphere;

Reference yield: 43.0%

(2S)-Methyl-1-azetidine-2-carboxylic acid (255882-95-2) + (4S,4aS,5aR,12aS)-8-amino-13-(dimethylamino)-9-[ (dimethylamino)methyl]-4a-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-10-fluoro-11a,12,12a,13-tetrahydro-5-hydroxy-3,7-bis(phenylmethoxy)-naphthaceno[2,3-d]isoxazole-4,6(4aH,11H)-dione (1207284-92-1) → C46H53FN4O8Si (1207284-94-3)

Guidance literature:

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 16.5h;

DOI:10.1021/jm201467r

Reference yield: 37.0%

4,6-dichloropyrimidine (1193-21-1) + (4S,4aS,5aR,12aS)-8-amino-13-(dimethylamino)-9-[ (dimethylamino)methyl]-4a-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-10-fluoro-11a,12,12a,13-tetrahydro-5-hydroxy-3,7-bis(phenylmethoxy)-naphthaceno[2,3-d]isoxazole-4,6(4aH,11H)-dione (1207284-92-1) → C45H47ClFN5O7Si (1207284-96-5)

Guidance literature:

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 80 ℃; for 4.5h; Inert atmosphere;

upstream raw materials:

(4S,4aS,5aR,12aS)-13-(dimethylamino)-4a-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-8-(di-2-propen-1-ylamino)-10-fluoro-11a,12,12a,13-tetrahydro-5-hydroxy-3,7-bis(phenylmethoxy)-naphthaceno[2,3-d]isoxazole-4,6(4aH,11H)-dione

Downstream raw materials:

C₄₅H₄₇ClFN₅O₇Si

C₆₀H₆₁FN₄O₁₀Si

C₄₆H₅₆FN₃O₇Si

C₄₆H₅₃FN₄O₈Si