C₂₁H₂₄ClN₈O₆P

Base Information

Chemical Name:C₂₁H₂₄ClN₈O₆P
CAS No.:1333995-40-6
Molecular Formula:C₂₁H₂₄ClN₈O₆P
Molecular Weight:550.898
Hs Code.:

C<sub>21</sub>H<sub>24</sub>ClN<sub>8</sub>O<sub>6</sub>P

Synonyms:C₂₁H₂₄ClN₈O₆P

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Chemical Property of C₂₁H₂₄ClN₈O₆P

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Technology Process of C₂₁H₂₄ClN₈O₆P

There total 7 articles about C₂₁H₂₄ClN₈O₆P which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 1333995-37-1
9-(3-azido-2,3-dideoxy-β-L-ribofuranosyl)-6-chloro-9H-purine

: 245078-14-2
(2S)-ethyl 2-(chloro(phenoxy)phosphorylamino)propanoate

: 1333995-40-6
C₂₁H₂₄ClN₈O₆P

Guidance literature:: 9-(3-azido-2,3-dideoxy-β-L-ribofuranosyl)-6-chloro-9H-purine; With tert-butylmagnesium chloride; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere;

(2S)-ethyl 2-(chloro(phenoxy)phosphorylamino)propanoate; In tetrahydrofuran; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.ejmech.2011.05.051

Reference yield:

: 1333995-33-7
9-(3-azido-5-O-tert-butyldimethylsilyl-2,3-dideoxy-β-L-ribofuranosyl)-6-chloro-9H-purine

: 1333995-40-6
C₂₁H₂₄ClN₈O₆P

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 5 h / Inert atmosphere

2.1: tert-butylmagnesium chloride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With tert-butylmagnesium chloride; tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran;
DOI:10.1016/j.ejmech.2011.05.051

Reference yield:

: 1333995-30-4
5'-O-tert-butyldiemthylsilyl-3'-azido-2',3'-dideoxy-β-L-thymidine

: 1333995-40-6
C₂₁H₂₄ClN₈O₆P

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,O-bis-(trimethylsilyl)-acetamide / acetonitrile / Reflux

1.2: 130 °C / Cooling with ice; Microwave irradiation

2.1: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 5 h / Inert atmosphere

3.1: tert-butylmagnesium chloride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

With N,O-bis-(trimethylsilyl)-acetamide; tert-butylmagnesium chloride; tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; acetonitrile;
DOI:10.1016/j.ejmech.2011.05.051