(+/-)-1-benzyloxycarbonylamino-3-methylbutylphosphonous acid

Base Information

• Chemical Name: (+/-)-1-benzyloxycarbonylamino-3-methylbutylphosphonous acid
• CAS No.: 109638-99-5
• Molecular Formula: C₁₃H₂₀NO₄P
• Molecular Weight: 285.28
• Mol file: 109638-99-5.mol

Synonyms:(+/-)-1-benzyloxycarbonylamino-3-methylbutylphosphonous acid

Chemical Property of (+/-)-1-benzyloxycarbonylamino-3-methylbutylphosphonous acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-1-benzyloxycarbonylamino-3-methylbutylphosphonous acid

There total 5 articles about (+/-)-1-benzyloxycarbonylamino-3-methylbutylphosphonous acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

benzyl chloroformate (501-53-1,94274-21-2) + 1-Amino-3-methyl-butylphosphonous acid (80744-65-6) → (+/-)-1-benzyloxycarbonylamino-3-methylbutylphosphonous acid (109638-99-5)

Guidance literature:

With sodium hydroxide; sodium hydrogencarbonate; sodium carbonate; at 22 ℃;

DOI:10.1021/jm00392a014

Reference yield:

[1-[(diphenylmethyl)amino]-3-methylbutyl]phosphinic acid (65577-21-1) → (+/-)-1-benzyloxycarbonylamino-3-methylbutylphosphonous acid (109638-99-5)

Guidance literature:

Multi-step reaction with 2 steps

1: HBr / 1 h / Heating

2: H₂O; dioxane / 24 h / pH 10

With hydrogen bromide; In 1,4-dioxane; water;

DOI:10.1080/00397910600767330

Reference yield:

isovaleraldehyde (590-86-3) → (+/-)-1-benzyloxycarbonylamino-3-methylbutylphosphonous acid (109638-99-5)

Guidance literature:

Multi-step reaction with 3 steps

1: ethanol / 5 h / Heating

2: aq. HBr / 1 h / Heating

3: H₂O; dioxane / 24 h / pH 10

With hydrogen bromide; In 1,4-dioxane; ethanol; water;

DOI:10.1016/j.tetlet.2005.03.083

upstream raw materials:

benzyl chloroformate

1-Amino-3-methyl-butylphosphonous acid

[1-[(diphenylmethyl)amino]-3-methylbutyl]phosphinic acid

isovaleraldehyde

Downstream raw materials:

methyl <1-<<(phenylmethoxy)carbonyl>amino>-3-methylbutyl>phosphinate

2-benzyl-3-[(1-benzyloxycarbonylamino-3-methyl-butyl)-hydroxy-phosphinoyl]-propionic acid ethyl ester

2-[(1-benzyloxycarbonylamino-3-methyl-butyl)-hydroxy-phosphinoylmethyl]-4-methyl-pentanoic acid methyl ester

methyl 3-{[1-(N-benzyloxycarbonylamino)-3-methylbutyl]hydroxyphosphinyl}propionate