1-4)-3,6-di-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranosyl)>-4,5-di-tert-butyloxycarbonyl-1,2,3-triazole

Base Information

Chemical Name:1-4)-3,6-di-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranosyl)>-4,5-di-tert-butyloxycarbonyl-1,2,3-triazole
CAS No.:188398-89-2
Molecular Formula:C₆₉H₇₄N₄O₁₆
Molecular Weight:1215.36
Hs Code.:

1-<O-(2-O-acetyl-3,4,6-tri-O-benzyl-β-D-galactopyranosyl)-(1<*>4)-3,6-di-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranosyl)>-4,5-di-tert-butyloxycarbonyl-1,2,3-triazole

Synonyms:1-4)-3,6-di-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranosyl)>-4,5-di-tert-butyloxycarbonyl-1,2,3-triazole

Suppliers and Price of 1-4)-3,6-di-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranosyl)>-4,5-di-tert-butyloxycarbonyl-1,2,3-triazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-4)-3,6-di-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranosyl)>-4,5-di-tert-butyloxycarbonyl-1,2,3-triazole

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-4)-3,6-di-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranosyl)>-4,5-di-tert-butyloxycarbonyl-1,2,3-triazole

There total 13 articles about 1-4)-3,6-di-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranosyl)>-4,5-di-tert-butyloxycarbonyl-1,2,3-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 66086-33-7
Di-tert-butyl acetylenedicarboxylate

: 188398-88-1
O-(2-O-acetyl-3,4,6-tri-O-benzyl-β-D-galactopyranosyl)-(1<*>4)-3,6-di-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranosyl azide

: 188398-89-2
1-4)-3,6-di-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranosyl)>-4,5-di-tert-butyloxycarbonyl-1,2,3-triazole

Guidance literature:: In toluene; at 100 ℃; for 72h;
DOI:10.1016/0008-6215(93)84071-D

Reference yield:

: 3068-32-4
1-bromo-2,3,4,6-tetra-O-acetyl-D-galactopyranose

: 188398-89-2
1-4)-3,6-di-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranosyl)>-4,5-di-tert-butyloxycarbonyl-1,2,3-triazole

Guidance literature:: Multi-step reaction with 7 steps

1: 2,6-lutidine, Bu₄NBr / nitromethane / 20 h / 40 °C

2: 0.1 M NaOMe / methanol / 1 h / Ambient temperature

3: 80percent NaH / dimethylformamide / 15 h / Ambient temperature

4: 1.) conc. H₂SO₄, 2.) pyridine / 1.) 1,4-dioxane, reflux, 2 h, 2.) RT, 16 h

5: 68 percent / HF, pyridine / CH₂Cl₂ / 3 h / 0 °C

6: 41 percent / 4A molecular sieves, BF₃*OEt₂ / CH₂Cl₂ / a) 0 deg C, 1 h, b) RT, 3 h

7: 68 percent / toluene / 72 h / 100 °C

With pyridine; 2,6-dimethylpyridine; 4 A molecular sieve; sulfuric acid; boron trifluoride diethyl etherate; hydrogen fluoride; tetrabutylammomium bromide; sodium methylate; sodium hydride; In methanol; nitromethane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/0008-6215(93)84071-D

Reference yield:

: 3254-15-7
3,4,6-tri-O-acetyl-1,2-O-(1-ethoxyethylidene)-α-D-galactopyranose

: 188398-89-2
1-4)-3,6-di-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranosyl)>-4,5-di-tert-butyloxycarbonyl-1,2,3-triazole

Guidance literature:: Multi-step reaction with 6 steps

1: 0.1 M NaOMe / methanol / 1 h / Ambient temperature

2: 80percent NaH / dimethylformamide / 15 h / Ambient temperature

3: 1.) conc. H₂SO₄, 2.) pyridine / 1.) 1,4-dioxane, reflux, 2 h, 2.) RT, 16 h

4: 68 percent / HF, pyridine / CH₂Cl₂ / 3 h / 0 °C

5: 41 percent / 4A molecular sieves, BF₃*OEt₂ / CH₂Cl₂ / a) 0 deg C, 1 h, b) RT, 3 h

6: 68 percent / toluene / 72 h / 100 °C

With pyridine; 4 A molecular sieve; sulfuric acid; boron trifluoride diethyl etherate; hydrogen fluoride; sodium methylate; sodium hydride; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/0008-6215(93)84071-D