cyclopropanecarboxylic acid {4-[4-(2-methyl-2H-pyrazol-3-yl)-phenyl]thiazol-2-yl}amide

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Chemical Name:cyclopropanecarboxylic acid {4-[4-(2-methyl-2H-pyrazol-3-yl)-phenyl]thiazol-2-yl}amide
CAS No.:1448015-81-3
Molecular Formula:C₁₇H₁₆N₄OS
Molecular Weight:324.406
Hs Code.:

Synonyms:cyclopropanecarboxylic acid {4-[4-(2-methyl-2H-pyrazol-3-yl)-phenyl]thiazol-2-yl}amide

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Chemical Property of cyclopropanecarboxylic acid {4-[4-(2-methyl-2H-pyrazol-3-yl)-phenyl]thiazol-2-yl}amide

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Technology Process of cyclopropanecarboxylic acid {4-[4-(2-methyl-2H-pyrazol-3-yl)-phenyl]thiazol-2-yl}amide

There total 3 articles about cyclopropanecarboxylic acid {4-[4-(2-methyl-2H-pyrazol-3-yl)-phenyl]thiazol-2-yl}amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 313405-50-4
cyclopropanecarboxylic acid [4-(4-bromophenyl)thiazol-2-yl]amide

: 720702-41-0
(1-methyl-1H-pyrazol-5-yl)boronic acid

: 1448015-81-3
cyclopropanecarboxylic acid {4-[4-(2-methyl-2H-pyrazol-3-yl)-phenyl]thiazol-2-yl}amide

Guidance literature:: With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; at 150 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;
DOI:10.1002/cmdc.201300007

Reference yield:

: 2103-94-8
4-(4-bromophenyl)-1,3-thiazol-2-amine

: 1448015-81-3
cyclopropanecarboxylic acid {4-[4-(2-methyl-2H-pyrazol-3-yl)-phenyl]thiazol-2-yl}amide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 24 h / 20 °C

2: tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate / 1,4-dioxane / 0.5 h / 150 °C / Inert atmosphere; Microwave irradiation

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-ethyl-N,N-diisopropylamine; tricyclohexylphosphine; In 1,4-dioxane; dichloromethane; 2: |Suzuki-Miyaura Coupling;
DOI:10.1002/cmdc.201300007

Reference yield:

: 99-73-0,132309-76-3
para-bromophenacyl bromide

: 1448015-81-3
cyclopropanecarboxylic acid {4-[4-(2-methyl-2H-pyrazol-3-yl)-phenyl]thiazol-2-yl}amide

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 18 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 24 h / 20 °C

3: tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate / 1,4-dioxane / 0.5 h / 150 °C / Inert atmosphere; Microwave irradiation

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-ethyl-N,N-diisopropylamine; tricyclohexylphosphine; In 1,4-dioxane; ethanol; dichloromethane; 1: |Hantzsch Thiazole Synthesis / 3: |Suzuki-Miyaura Coupling;
DOI:10.1002/cmdc.201300007