N-{3-[2-(2-acetyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-ethyl]-4-methylphenyl}-3-hydroxy-4-trifluoromethylbenzamide

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Chemical Name:N-{3-[2-(2-acetyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-ethyl]-4-methylphenyl}-3-hydroxy-4-trifluoromethylbenzamide
CAS No.:1616689-33-8
Molecular Formula:C₂₆H₂₂F₃N₃O₃
Molecular Weight:481.474
Hs Code.:

Synonyms:N-{3-[2-(2-acetyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-ethyl]-4-methylphenyl}-3-hydroxy-4-trifluoromethylbenzamide

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Chemical Property of N-{3-[2-(2-acetyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-ethyl]-4-methylphenyl}-3-hydroxy-4-trifluoromethylbenzamide

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Technology Process of N-{3-[2-(2-acetyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-ethyl]-4-methylphenyl}-3-hydroxy-4-trifluoromethylbenzamide

There total 5 articles about N-{3-[2-(2-acetyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-ethyl]-4-methylphenyl}-3-hydroxy-4-trifluoromethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 1616689-81-6
1-{5-[2-(5-amino-2-methylphenyl)-ethyl]-1H-pyrrolo[2,3-b]pyridin-2-yl}-ethanone

: 126541-87-5
3-hydroxy-4-trifluoromethylbenzoic acid

: 1616689-33-8
N-{3-[2-(2-acetyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-ethyl]-4-methylphenyl}-3-hydroxy-4-trifluoromethylbenzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

Reference yield:

: 1616689-94-1
2-acetyl-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile

: 1616689-33-8
N-{3-[2-(2-acetyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-ethyl]-4-methylphenyl}-3-hydroxy-4-trifluoromethylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1: diisobutylaluminium hydride / toluene / 1.5 h / 0 °C

2: manganese(IV) oxide / tetrahydrofuran / 20 °C

3: lithium hydroxide / methanol / 20 °C

4: hydrogen; palladium 10% on activated carbon / N,N-dimethyl-formamide / 7500.75 Torr

5: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 12 h / 20 °C

With manganese(IV) oxide; palladium 10% on activated carbon; hydrogen; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1616689-78-1
2-(1-hydroxyethyl)-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde

: 1616689-33-8
N-{3-[2-(2-acetyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-ethyl]-4-methylphenyl}-3-hydroxy-4-trifluoromethylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: manganese(IV) oxide / tetrahydrofuran / 20 °C

2: lithium hydroxide / methanol / 20 °C

3: hydrogen; palladium 10% on activated carbon / N,N-dimethyl-formamide / 7500.75 Torr

4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 12 h / 20 °C

With manganese(IV) oxide; palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;