1D-(1,2,4/3,5)-2-amino-1,2-N,O-carbonyl-3-O-<(R)-2'-propanoyl-L-alanyl-D-isoglutamine benzylester>-5-C-hydroxymethyl-1,3,4-cyclohexane-triol

Base Information

Chemical Name:1D-(1,2,4/3,5)-2-amino-1,2-N,O-carbonyl-3-O-<(R)-2'-propanoyl-L-alanyl-D-isoglutamine benzylester>-5-C-hydroxymethyl-1,3,4-cyclohexane-triol
CAS No.:121788-71-4
Molecular Formula:C₃₃H₄₀N₄O₁₀
Molecular Weight:652.701
Hs Code.:

Synonyms:1D-(1,2,4/3,5)-2-amino-1,2-N,O-carbonyl-3-O-<(R)-2'-propanoyl-L-alanyl-D-isoglutamine benzylester>-5-C-hydroxymethyl-1,3,4-cyclohexane-triol

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Chemical Property of 1D-(1,2,4/3,5)-2-amino-1,2-N,O-carbonyl-3-O-<(R)-2'-propanoyl-L-alanyl-D-isoglutamine benzylester>-5-C-hydroxymethyl-1,3,4-cyclohexane-triol

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Technology Process of 1D-(1,2,4/3,5)-2-amino-1,2-N,O-carbonyl-3-O-<(R)-2'-propanoyl-L-alanyl-D-isoglutamine benzylester>-5-C-hydroxymethyl-1,3,4-cyclohexane-triol

There total 15 articles about 1D-(1,2,4/3,5)-2-amino-1,2-N,O-carbonyl-3-O-<(R)-2'-propanoyl-L-alanyl-D-isoglutamine benzylester>-5-C-hydroxymethyl-1,3,4-cyclohexane-triol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 121788-70-3
(R)-2-((3aS,4R,4aR,6R,8aR,9aS)-2-Oxo-6-phenyl-octahydro-1,5,7-trioxa-3-aza-cyclopenta[b]naphthalen-4-yloxy)-propionic acid

: 62853-36-5,71822-09-8,85546-24-3
L-ala-D-isoglutamine benzyl ester

: 121788-71-4
1D-(1,2,4/3,5)-2-amino-1,2-N,O-carbonyl-3-O-<(R)-2'-propanoyl-L-alanyl-D-isoglutamine benzylester>-5-C-hydroxymethyl-1,3,4-cyclohexane-triol

Guidance literature:: With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide;
DOI:10.1021/jo00277a002

Reference yield:

: 121788-68-9
(3aR,4R,5R,6R,7aS)-4,5-dihydroxy-6-(hydroxymethyl)hexahydrobenzo[d]oxazol-2(3H)-one

: 121788-71-4
1D-(1,2,4/3,5)-2-amino-1,2-N,O-carbonyl-3-O-<(R)-2'-propanoyl-L-alanyl-D-isoglutamine benzylester>-5-C-hydroxymethyl-1,3,4-cyclohexane-triol

Guidance literature:: Multi-step reaction with 3 steps

1: ZnCl₂

2: 72 percent / NaH / dimethylformamide

3: 78 percent / N-hydroxysuccinimide, dicyclohexylcarbodiimide

With 1-hydroxy-pyrrolidine-2,5-dione; sodium hydride; dicyclohexyl-carbodiimide; zinc(II) chloride; In N,N-dimethyl-formamide;
DOI:10.1021/jo00277a002

Reference yield:

: 121788-69-0
1D-(1,2,4/3,5)-2-amino-1,2-N,O-carbonyl-4,7-benzylidene-5-C-hydroxymethyl-1,3,4-cyclohexanetriol

: 121788-71-4
1D-(1,2,4/3,5)-2-amino-1,2-N,O-carbonyl-3-O-<(R)-2'-propanoyl-L-alanyl-D-isoglutamine benzylester>-5-C-hydroxymethyl-1,3,4-cyclohexane-triol

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / NaH / dimethylformamide

2: 78 percent / N-hydroxysuccinimide, dicyclohexylcarbodiimide

With 1-hydroxy-pyrrolidine-2,5-dione; sodium hydride; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;
DOI:10.1021/jo00277a002