4-(5-((2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)(propyl)amino)pentyl)benzene-1,2-diol

Base Information

Chemical Name:4-(5-((2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)(propyl)amino)pentyl)benzene-1,2-diol
CAS No.:1612146-64-1
Molecular Formula:C₂₁H₃₁N₃O₂S
Molecular Weight:389.562
Hs Code.:

Synonyms:4-(5-((2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)(propyl)amino)pentyl)benzene-1,2-diol

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Chemical Property of 4-(5-((2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)(propyl)amino)pentyl)benzene-1,2-diol

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Technology Process of 4-(5-((2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)(propyl)amino)pentyl)benzene-1,2-diol

There total 4 articles about 4-(5-((2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)(propyl)amino)pentyl)benzene-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1612146-61-8
4-(5-((2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)(propyl)amino)pentyl)-2-methoxyphenol

: 1612146-64-1
4-(5-((2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)(propyl)amino)pentyl)benzene-1,2-diol

Guidance literature:: With boron tribromide; In dichloromethane; at -78 - 0 ℃; for 6h;

Reference yield:

: (Z)-ethyl 5-(4-hydroxy-3-methoxyphenyl)pent-4-enoate

: 1612146-64-1
4-(5-((2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)(propyl)amino)pentyl)benzene-1,2-diol

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen; palladium 10% on activated carbon / ethanol / 2 h / 20 °C

2.1: diisobutylaluminium hydride / toluene; hexane / 2 h / -78 °C / Inert atmosphere

3.1: dichloromethane / 1 h / Inert atmosphere

3.2: 36 h / 20 °C / Inert atmosphere

4.1: boron tribromide / dichloromethane / 6 h / -78 - 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; boron tribromide; diisobutylaluminium hydride; In ethanol; hexane; dichloromethane; toluene;
DOI:10.1016/j.bmc.2016.08.021

Reference yield:

: ethyl 5-(4-hydroxy-3-methoxyphenyl)pentanoate

: 1612146-64-1
4-(5-((2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)(propyl)amino)pentyl)benzene-1,2-diol

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisobutylaluminium hydride / toluene; hexane / 2 h / -78 °C / Inert atmosphere

2.1: dichloromethane / 1 h / Inert atmosphere

2.2: 36 h / 20 °C / Inert atmosphere

3.1: boron tribromide / dichloromethane / 6 h / -78 - 20 °C / Inert atmosphere

With boron tribromide; diisobutylaluminium hydride; In hexane; dichloromethane; toluene;
DOI:10.1016/j.bmc.2016.08.021