tert-butyl 4-((2-(5-(3,5-dimethoxybenzyl)-1,2,4-oxadiazol-3-yl)benzo[b]thiophen-3-yl)oxy)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-((2-(5-(3,5-dimethoxybenzyl)-1,2,4-oxadiazol-3-yl)benzo[b]thiophen-3-yl)oxy)piperidine-1-carboxylate
CAS No.:1581303-57-2
Molecular Formula:C₂₉H₃₃N₃O₆S
Molecular Weight:551.664
Hs Code.:

Synonyms:tert-butyl 4-((2-(5-(3,5-dimethoxybenzyl)-1,2,4-oxadiazol-3-yl)benzo[b]thiophen-3-yl)oxy)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-((2-(5-(3,5-dimethoxybenzyl)-1,2,4-oxadiazol-3-yl)benzo[b]thiophen-3-yl)oxy)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-((2-(5-(3,5-dimethoxybenzyl)-1,2,4-oxadiazol-3-yl)benzo[b]thiophen-3-yl)oxy)piperidine-1-carboxylate

There total 5 articles about tert-butyl 4-((2-(5-(3,5-dimethoxybenzyl)-1,2,4-oxadiazol-3-yl)benzo[b]thiophen-3-yl)oxy)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₉H₃₅N₃O₇S

: 1581303-57-2
tert-butyl 4-((2-(5-(3,5-dimethoxybenzyl)-1,2,4-oxadiazol-3-yl)benzo[b]thiophen-3-yl)oxy)piperidine-1-carboxylate

Guidance literature:: In toluene; at 110 ℃; for 18h; Molecular sieve;
DOI:10.1021/jm500066b

Reference yield:

: 1581303-59-4
(Z)-tert-butyl 4-((2-(N'-hydroxycarbamimidoyl)benzo[b]thiophen-3-yl)oxy)piperidine-1-carboxylate

: 1581303-57-2
tert-butyl 4-((2-(5-(3,5-dimethoxybenzyl)-1,2,4-oxadiazol-3-yl)benzo[b]thiophen-3-yl)oxy)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 0.25 h / 20 °C

1.2: 18 h / 20 °C

2.1: toluene / 18 h / 110 °C / Molecular sieve

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In toluene; acetonitrile;
DOI:10.1021/jm500066b

Reference yield:

: 1581303-58-3
tert-butyl 4-((2-cyanobenzo[b]thiophen-3-yl)oxy)piperidine-1-carboxylate

: 1581303-57-2
tert-butyl 4-((2-(5-(3,5-dimethoxybenzyl)-1,2,4-oxadiazol-3-yl)benzo[b]thiophen-3-yl)oxy)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydroxylamine / ethanol; water / 4 h / Reflux

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 0.25 h / 20 °C

2.2: 18 h / 20 °C

3.1: toluene / 18 h / 110 °C / Molecular sieve

With hydroxylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; water; toluene; acetonitrile;
DOI:10.1021/jm500066b