1-(1H-benzo[d]imidazol-2-yl)-N-(4-fluorophenyl)-2-(4-hydroxy-3-methoxyphenyl)ethanesulfonamide

Base Information

Chemical Name:1-(1H-benzo[d]imidazol-2-yl)-N-(4-fluorophenyl)-2-(4-hydroxy-3-methoxyphenyl)ethanesulfonamide
CAS No.:1430475-88-9
Molecular Formula:C₂₂H₂₀FN₃O₄S
Molecular Weight:441.483
Hs Code.:

Synonyms:1-(1H-benzo[d]imidazol-2-yl)-N-(4-fluorophenyl)-2-(4-hydroxy-3-methoxyphenyl)ethanesulfonamide

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Chemical Property of 1-(1H-benzo[d]imidazol-2-yl)-N-(4-fluorophenyl)-2-(4-hydroxy-3-methoxyphenyl)ethanesulfonamide

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Technology Process of 1-(1H-benzo[d]imidazol-2-yl)-N-(4-fluorophenyl)-2-(4-hydroxy-3-methoxyphenyl)ethanesulfonamide

There total 4 articles about 1-(1H-benzo[d]imidazol-2-yl)-N-(4-fluorophenyl)-2-(4-hydroxy-3-methoxyphenyl)ethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1430475-81-2
1-(1H-benzo[d]imidazol-2-yl)-N-(4-fluorophenyl)-2-(4-hydroxy-3-methoxyphenyl)ethenesulfonamide

: 1430475-88-9
1-(1H-benzo[d]imidazol-2-yl)-N-(4-fluorophenyl)-2-(4-hydroxy-3-methoxyphenyl)ethanesulfonamide

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 16h;
DOI:10.1016/j.bmcl.2013.02.109

Reference yield:

: 1430475-71-0
ethyl 2-[N-(4-fluorophenyl)sulfamoyl]acetate

: 1430475-88-9
1-(1H-benzo[d]imidazol-2-yl)-N-(4-fluorophenyl)-2-(4-hydroxy-3-methoxyphenyl)ethanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium hydroxide / water / 16 h / 20 °C

2: Lawessons reagent / neat (no solvent) / 2 h / 150 °C / Sealed tube

3: chloro-trimethyl-silane / N,N-dimethyl-formamide / 1.5 h / 135 °C / Sealed tube

4: palladium 10% on activated carbon; hydrogen / methanol / 16 h / 20 °C

With Lawessons reagent; chloro-trimethyl-silane; palladium 10% on activated carbon; hydrogen; potassium hydroxide; In methanol; water; N,N-dimethyl-formamide; 3: |Knoevenagel Condensation;
DOI:10.1016/j.bmcl.2013.02.109

Reference yield:

: 1430475-73-2
1-(1H-benzo[d]imidazol-2-yl)-N-(4-fluorophenyl)methanesulfonamide

: 1430475-88-9
1-(1H-benzo[d]imidazol-2-yl)-N-(4-fluorophenyl)-2-(4-hydroxy-3-methoxyphenyl)ethanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: chloro-trimethyl-silane / N,N-dimethyl-formamide / 1.5 h / 135 °C / Sealed tube

2: palladium 10% on activated carbon; hydrogen / methanol / 16 h / 20 °C

With chloro-trimethyl-silane; palladium 10% on activated carbon; hydrogen; In methanol; N,N-dimethyl-formamide; 1: |Knoevenagel Condensation;
DOI:10.1016/j.bmcl.2013.02.109