Azetidin-3-ol

Base Information

• Chemical Name: Azetidin-3-ol
• CAS No.: 45347-82-8
• Molecular Formula: C3H7NO
• Molecular Weight: 73.0947
• Hs Code.: 2933990090
• European Community (EC) Number: 830-570-3
• DSSTox Substance ID: DTXSID30363837
• Nikkaji Number: J36.167D
• Wikidata: Q72483191
• Mol file: 45347-82-8.mol

Synonyms:Azetidin-3-ol;45347-82-8;3-Azetidinol;3-hydroxyazetidine;azetidine-3-ol;XKS;3-hydroxy-azetidine;DTXSID30363837;BCP23318;STR08059;AC-092;BBL023120;MFCD03695446;STL356019;AKOS009171357;s11377;A7152;AM20100158;CS-0084651;FT-0658863;EN300-66510;A19977;Q-103245

Chemical Property of Azetidin-3-ol

Chemical Property:

• Vapor Pressure: 0.464mmHg at 25°C
• Refractive Index: 1.498
• Boiling Point: 170.7 °C at 760 mmHg
• PKA: 14.51±0.20(Predicted)
• Flash Point: 120.4 °C
• PSA: 32.26000
• Density: 1.142 g/cm³
• LogP: -0.72070
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: -1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 73.052763847
• Heavy Atom Count: 5
• Complexity: 33.9

Purity/Quality:

98%, ^*data from raw suppliers

Azetidin-3-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(CN1)O

Technology Process of Azetidin-3-ol

There total 10 articles about Azetidin-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(diphenylmethyl)-3-hydroxyazetidine (18621-17-5) → azetidine-3-ol (45347-82-8) + Diphenylmethane (101-81-5)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In methanol; at 39.99 ℃; under 15751.6 Torr; Reagent/catalyst; Solvent; Kinetics; Flow reactor;

DOI:10.1021/acs.oprd.9b00416

Reference yield:

1-(diphenylmethyl)-3-hydroxyazetidine (18621-17-5) → azetidine-3-ol (45347-82-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 20h;

DOI:10.1021/jm00056a006

Reference yield:

tert-butyl 3-hydroxyazetidine-1-carboxylate (141699-55-0) → azetidine-3-ol (45347-82-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

upstream raw materials:

1-(diphenylmethyl)-3-hydroxyazetidine

N-benzyl-3-(trimethylsilyloxy)azetidine

tert-butyl 3-hydroxyazetidine-1-carboxylate

3-Amino-1,2-propanediol

Downstream raw materials:

1-Benzyloxycarbonyl-3-hydroxyazetidine

tert-butyl 3-hydroxyazetidine-1-carboxylate

4-butoxy-benzenesulfonic acid 1-(4-butoxy-benzenesulfonyl)-azetidin-3-yl ester

1-(4-phenoxybenzyl)azetidin-3-ol