Technology Process of 6-METHYL-2-PYRIDINEALDOXIME
There total 5 articles about 6-METHYL-2-PYRIDINEALDOXIME which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydroxylamine hydrochloride; potassium carbonate;
In
ethanol; water;
for 0.5h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 2,2,2-Trifluoroacetophenone; dihydrogen peroxide; potassium carbonate / tert-butyl alcohol; acetonitrile; water / 28 h / 23 °C
2.1: trifluoroacetic anhydride / dichloromethane / 42 h / 23 °C / Inert atmosphere
2.2: 3 h / 0 - 23 °C / Inert atmosphere
3.1: manganese(IV) oxide / 1,2-dichloro-ethane / 22 h / Inert atmosphere; Reflux
4.1: hydroxylamine hydrochloride; potassium carbonate / water; methanol / 3 h / Reflux
With
manganese(IV) oxide; 2,2,2-Trifluoroacetophenone; hydroxylamine hydrochloride; dihydrogen peroxide; potassium carbonate; trifluoroacetic anhydride;
In
methanol; dichloromethane; water; 1,2-dichloro-ethane; acetonitrile; tert-butyl alcohol;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: trifluoroacetic anhydride / dichloromethane / 48 h / 23 °C / Inert atmosphere; Schlenk technique
2: manganese(IV) oxide / 1,2-dichloro-ethane / 22 h / Inert atmosphere; Schlenk technique; Reflux
3: potassium carbonate; hydroxylamine hydrochloride / water; methanol / 3 h / Reflux
With
manganese(IV) oxide; hydroxylamine hydrochloride; potassium carbonate; trifluoroacetic anhydride;
In
methanol; dichloromethane; water; 1,2-dichloro-ethane;
DOI:10.1021/acsmedchemlett.9b00586
