(3E)-3-[[3-[[5-(Trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]-cyclohexanamine

Base Information

Chemical Name:(3E)-3-[[3-[[5-(Trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]-cyclohexanamine
CAS No.:1428929-25-2
Molecular Formula:C₁₉H₁₉F₃N₂O
Molecular Weight:348.368
Hs Code.:

Synonyms:(3E)-3-[[3-[[5-(Trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]-cyclohexanamine

Suppliers and Price of (3E)-3-[[3-[[5-(Trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]-cyclohexanamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3E)-3-[[3-[[5-(Trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]-cyclohexanamine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3E)-3-[[3-[[5-(Trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]-cyclohexanamine

There total 8 articles about (3E)-3-[[3-[[5-(Trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]-cyclohexanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1428929-24-1
tert-butyl N-[(3E)-3-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]-methylene]cyclohexyl]carbamate

: 1428929-25-2
(3E)-3-[[3-[[5-(Trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]-cyclohexanamine

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 8h;

Reference yield:

: 1020333-02-1
3-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzaldehyde

: 1428929-25-2
(3E)-3-[[3-[[5-(Trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]-cyclohexanamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate / methanol / 1 h / 0 °C

2.1: thionyl chloride / dichloromethane / 1 h / 0 - 20 °C

3.1: 18 h / 150 °C

4.1: sodium hydride / mineral oil; tetrahydrofuran / 3.5 h / 0 - 20 °C

4.2: 19 h / 0 - 20 °C

5.1: hydrogenchloride / 1,4-dioxane / 8 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; thionyl chloride; sodium hydride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; mineral oil; 4.1: |Wittig-Horner Reaction;

Reference yield:

: 100-83-4
meta-hydroxybenzaldehyde

: 1428929-25-2
(3E)-3-[[3-[[5-(Trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]-cyclohexanamine

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 100 °C

2.1: sodium tetrahydroborate / methanol / 1 h / 0 °C

3.1: thionyl chloride / dichloromethane / 1 h / 0 - 20 °C

4.1: 18 h / 150 °C

5.1: sodium hydride / mineral oil; tetrahydrofuran / 3.5 h / 0 - 20 °C

5.2: 19 h / 0 - 20 °C

6.1: hydrogenchloride / 1,4-dioxane / 8 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; thionyl chloride; sodium hydride; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil; 5.1: |Wittig-Horner Reaction;