6(R)-<2-<8-hydroxy-2(S),6(S)-dimethyl-7(S)-<1(S)-hydroxybenzyl>-1,2,6,7,8,8a(R)-hexahydronaphthyl-1(S)>ethyl>-4(R)-<(tert-butyldimethylsilyl)oxy>-3,4,5,6-tetrahydro-2H-pyran-2-one

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Chemical Name:6(R)-<2-<8-hydroxy-2(S),6(S)-dimethyl-7(S)-<1(S)-hydroxybenzyl>-1,2,6,7,8,8a(R)-hexahydronaphthyl-1(S)>ethyl>-4(R)-<(tert-butyldimethylsilyl)oxy>-3,4,5,6-tetrahydro-2H-pyran-2-one
CAS No.:143746-98-9
Molecular Formula:C₃₂H₄₈O₅Si
Molecular Weight:540.816
Hs Code.:

6(R)-<2-<8-hydroxy-2(S),6(S)-dimethyl-7(S)-<1(S)-hydroxybenzyl>-1,2,6,7,8,8a(R)-hexahydronaphthyl-1(S)>ethyl>-4(R)-<(tert-butyldimethylsilyl)oxy>-3,4,5,6-tetrahydro-2H-pyran-2-one

Synonyms:6(R)-<2-<8-hydroxy-2(S),6(S)-dimethyl-7(S)-<1(S)-hydroxybenzyl>-1,2,6,7,8,8a(R)-hexahydronaphthyl-1(S)>ethyl>-4(R)-<(tert-butyldimethylsilyl)oxy>-3,4,5,6-tetrahydro-2H-pyran-2-one

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Chemical Property of 6(R)-<2-<8-hydroxy-2(S),6(S)-dimethyl-7(S)-<1(S)-hydroxybenzyl>-1,2,6,7,8,8a(R)-hexahydronaphthyl-1(S)>ethyl>-4(R)-<(tert-butyldimethylsilyl)oxy>-3,4,5,6-tetrahydro-2H-pyran-2-one

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Technology Process of 6(R)-<2-<8-hydroxy-2(S),6(S)-dimethyl-7(S)-<1(S)-hydroxybenzyl>-1,2,6,7,8,8a(R)-hexahydronaphthyl-1(S)>ethyl>-4(R)-<(tert-butyldimethylsilyl)oxy>-3,4,5,6-tetrahydro-2H-pyran-2-one

There total 5 articles about 6(R)-<2-<8-hydroxy-2(S),6(S)-dimethyl-7(S)-<1(S)-hydroxybenzyl>-1,2,6,7,8,8a(R)-hexahydronaphthyl-1(S)>ethyl>-4(R)-<(tert-butyldimethylsilyl)oxy>-3,4,5,6-tetrahydro-2H-pyran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 143746-96-7
6(R)-<2-<8-oxo-2(S),6(S)-dimethyl-7(S)-<1(S)-hydroxybenzyl>-1,2,6,7,8,8a(R)-hexahydronaphthyl-1(S)>ethyl>-4(R)-<(tert-butyldimethylsilyl)oxy>-3,4,5,6-tetrahydro-2H-pyran-2-one

: 143746-98-9
6(R)-<2-<8-hydroxy-2(S),6(S)-dimethyl-7(S)-<1(S)-hydroxybenzyl>-1,2,6,7,8,8a(R)-hexahydronaphthyl-1(S)>ethyl>-4(R)-<(tert-butyldimethylsilyl)oxy>-3,4,5,6-tetrahydro-2H-pyran-2-one

Guidance literature:: With sodium tetrahydroborate; palladium dichloride; In tetrahydrofuran; water; at -30 - -5 ℃;
DOI:10.1021/jm00099a009

Reference yield:

: 79902-31-1
(4R,6R)-6-[2-((1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthyl)ethyl]-4-[(tert-butyldimethylsilyl)oxy]-3,4,5,6-tetrahydro-2H-pyran-2-one

: 143746-98-9
6(R)-<2-<8-hydroxy-2(S),6(S)-dimethyl-7(S)-<1(S)-hydroxybenzyl>-1,2,6,7,8,8a(R)-hexahydronaphthyl-1(S)>ethyl>-4(R)-<(tert-butyldimethylsilyl)oxy>-3,4,5,6-tetrahydro-2H-pyran-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) oxalyl chloride, dimethyl sulfoxide, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 30 min, 2.) CH₂Cl₂, 20 min

2: triethylamine / CH₂Cl₂ / 0.5 h / 0 °C

3: H₂O / CH₂Cl₂ / 0.08 h

4: 32 percent / TiCl₄ / CH₂Cl₂ / 2.75 h / -70 - -45 °C

5: 57 percent / NaBH₄, PdCl₂ / tetrahydrofuran; H₂O / -30 - -5 °C

With sodium tetrahydroborate; oxalyl dichloride; water; titanium tetrachloride; dimethyl sulfoxide; triethylamine; palladium dichloride; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jm00099a009

Reference yield:

: 136432-01-4
6(R)-<2-<8-oxo-2(S),6(R)-dimethyl-1,2,6,7,8,8a(R)-hexahydronaphthyl-1(S)>ethyl>-4(R)-<(tert-butyldimethylsilyl)oxy>-3,4,5,6-tetrahydro-2H-pyran-2-one

: 143746-98-9
6(R)-<2-<8-hydroxy-2(S),6(S)-dimethyl-7(S)-<1(S)-hydroxybenzyl>-1,2,6,7,8,8a(R)-hexahydronaphthyl-1(S)>ethyl>-4(R)-<(tert-butyldimethylsilyl)oxy>-3,4,5,6-tetrahydro-2H-pyran-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / CH₂Cl₂ / 0.5 h / 0 °C

2: H₂O / CH₂Cl₂ / 0.08 h

3: 32 percent / TiCl₄ / CH₂Cl₂ / 2.75 h / -70 - -45 °C

4: 57 percent / NaBH₄, PdCl₂ / tetrahydrofuran; H₂O / -30 - -5 °C

With sodium tetrahydroborate; water; titanium tetrachloride; triethylamine; palladium dichloride; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jm00099a009