(S)-3-Benzenesulfonyl-3-((R)-3-{(2R,6R)-6-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3,6-dihydro-2H-pyran-2-yl}-2-methyl-propyl)-5-(4-methoxy-benzyloxymethyl)-dihydro-furan-2-one

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Chemical Name:(S)-3-Benzenesulfonyl-3-((R)-3-{(2R,6R)-6-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3,6-dihydro-2H-pyran-2-yl}-2-methyl-propyl)-5-(4-methoxy-benzyloxymethyl)-dihydro-furan-2-one
CAS No.:312695-79-7
Molecular Formula:C₃₆H₅₂O₈SSi
Molecular Weight:672.956
Hs Code.:

(S)-3-Benzenesulfonyl-3-((R)-3-{(2R,6R)-6-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3,6-dihydro-2H-pyran-2-yl}-2-methyl-propyl)-5-(4-methoxy-benzyloxymethyl)-dihydro-furan-2-one

Synonyms:(S)-3-Benzenesulfonyl-3-((R)-3-{(2R,6R)-6-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3,6-dihydro-2H-pyran-2-yl}-2-methyl-propyl)-5-(4-methoxy-benzyloxymethyl)-dihydro-furan-2-one

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Chemical Property of (S)-3-Benzenesulfonyl-3-((R)-3-{(2R,6R)-6-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3,6-dihydro-2H-pyran-2-yl}-2-methyl-propyl)-5-(4-methoxy-benzyloxymethyl)-dihydro-furan-2-one

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Technology Process of (S)-3-Benzenesulfonyl-3-((R)-3-{(2R,6R)-6-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3,6-dihydro-2H-pyran-2-yl}-2-methyl-propyl)-5-(4-methoxy-benzyloxymethyl)-dihydro-furan-2-one

There total 14 articles about (S)-3-Benzenesulfonyl-3-((R)-3-{(2R,6R)-6-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3,6-dihydro-2H-pyran-2-yl}-2-methyl-propyl)-5-(4-methoxy-benzyloxymethyl)-dihydro-furan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 273733-96-3
(5S)-5-(p-methoxy-benzyl)-methyl-3-phenyl-sulphonyl-dihydrofuran-2-one

: 312695-78-6
(2R,6S)-tert-butyl-(2-{6-[(2R)-3-iodo-2-methyl-propyl]-5,6-dihydro-2H-pyran-2-yl}-ethoxy)-dimethyl-silane

: 312695-79-7
(S)-3-Benzenesulfonyl-3-((R)-3-{(2R,6R)-6-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3,6-dihydro-2H-pyran-2-yl}-2-methyl-propyl)-5-(4-methoxy-benzyloxymethyl)-dihydro-furan-2-one

Guidance literature:: (5S)-5-(p-methoxy-benzyl)-methyl-3-phenyl-sulphonyl-dihydrofuran-2-one; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.25h;

(2R,6S)-tert-butyl-(2-{6-[(2R)-3-iodo-2-methyl-propyl]-5,6-dihydro-2H-pyran-2-yl}-ethoxy)-dimethyl-silane; In N,N-dimethyl-formamide; at 23 - 60 ℃; for 12.25h;
DOI:10.1021/ja0027416

Reference yield:

: 34097-60-4
methyl benzenesulfonylacetate

: 312695-79-7
(S)-3-Benzenesulfonyl-3-((R)-3-{(2R,6R)-6-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3,6-dihydro-2H-pyran-2-yl}-2-methyl-propyl)-5-(4-methoxy-benzyloxymethyl)-dihydro-furan-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 83 percent / NaH / ethanol; various solvent(s) / 12 h / 23 °C

2.1: NaH / dimethylformamide; various solvent(s) / 0.25 h / 0 °C

2.2: 89 percent / dimethylformamide / 12 h / 60 °C

With sodium hydride; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jo010854h

Reference yield:

: 312695-89-9
2-[(2R,6S)-6-((R)-3-Benzyloxy-2-methyl-propyl)-5,6-dihydro-2H-pyran-2-yl]-ethanol

: 312695-79-7
(S)-3-Benzenesulfonyl-3-((R)-3-{(2R,6R)-6-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3,6-dihydro-2H-pyran-2-yl}-2-methyl-propyl)-5-(4-methoxy-benzyloxymethyl)-dihydro-furan-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 75 percent / imidazole / dimethylformamide / 3 h / 23 °C

2.1: 95 percent / Li; liquid NH₃ / tetrahydrofuran / 0.17 h

3.1: 96 percent / I₂; imidazole; PPh₃ / diethyl ether; acetonitrile / 0.5 h / 0 °C

4.1: NaH / dimethylformamide; various solvent(s) / 0.25 h / 0 °C

4.2: 89 percent / dimethylformamide / 12 h / 60 °C

With 1H-imidazole; ammonia; iodine; lithium; sodium hydride; triphenylphosphine; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo010854h