((2R,3S,4S)-4-hydroxy-2-phenyltetrahydrothiophen-3-yl)(phenyl)methanone

Base Information

• Chemical Name: ((2R,3S,4S)-4-hydroxy-2-phenyltetrahydrothiophen-3-yl)(phenyl)methanone
• CAS No.: 1357912-46-9
• Molecular Formula: C₁₇H₁₆O₂S
• Molecular Weight: 284.379
• Mol file: 1357912-46-9.mol

Synonyms:((2R,3S,4S)-4-hydroxy-2-phenyltetrahydrothiophen-3-yl)(phenyl)methanone

Chemical Property of ((2R,3S,4S)-4-hydroxy-2-phenyltetrahydrothiophen-3-yl)(phenyl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of ((2R,3S,4S)-4-hydroxy-2-phenyltetrahydrothiophen-3-yl)(phenyl)methanone

There total 5 articles about ((2R,3S,4S)-4-hydroxy-2-phenyltetrahydrothiophen-3-yl)(phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1,4-dithiane-2,5-diol (40018-26-6) + benzalacetophenone (94-41-7) → ((2R,3S,4S)-4-hydroxy-2-phenyltetrahydrothiophen-3-yl)(phenyl)methanone (1357912-46-9)

Guidance literature:

With potassium fluoride; C₄₆H₃₄I₄O₆; In dichloromethane; at 20 ℃; for 24h; Solvent; stereoselective reaction; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.orglett.7b00813

Reference yield: 35.0%

1,4-dithiane-2,5-diol (40018-26-6) + 3-((4-chlorophenyl)sulfonyl)-1,3-diphenylpropan-1-one → ((2R,3S,4S)-4-hydroxy-2-phenyltetrahydrothiophen-3-yl)(phenyl)methanone (1357912-46-9) + (R)-3-((4-chlorophenyl)sulfonyl)-1,3-diphenylpropan-1-one

Guidance literature:

With potassium fluoride; C₄₆H₃₄I₄O₆; In dichloromethane; at 20 ℃; for 48h; stereoselective reaction; Inert atmosphere; Schlenk technique; Resolution of racemate;

DOI:10.1016/j.cclet.2018.01.047

Reference yield:

1,4-dithiane-2,5-diol (40018-26-6) + benzalacetophenone (94-41-7) → ((2S,3R,4R)-4-hydroxy-2-phenyltetrahydrothiophen-3-yl)(phenyl)methanone (1357912-62-9) + ((2R,3S,4S)-4-hydroxy-2-phenyltetrahydrothiophen-3-yl)(phenyl)methanone (1357912-46-9)

Guidance literature:

With C₃₂H₂₈F₆N₄O₃; In toluene; at 20 ℃; for 48h; optical yield given as %ee; enantioselective reaction;

DOI:10.1021/ol2034959

upstream raw materials:

1,4-dithiane-2,5-diol

benzalacetophenone

4-chlorobenzenesulfinic acid