4-amino-7-[2-deoxy-2,2-difluoro-α-D-erythro-pentofuranosyl]-5-phenylpyrrolo[2,3-d]pyrimidine

Base Information

Chemical Name:4-amino-7-[2-deoxy-2,2-difluoro-α-D-erythro-pentofuranosyl]-5-phenylpyrrolo[2,3-d]pyrimidine
CAS No.:1440537-19-8
Molecular Formula:C₁₇H₁₆F₂N₄O₃
Molecular Weight:362.336
Hs Code.:

Synonyms:4-amino-7-[2-deoxy-2,2-difluoro-α-D-erythro-pentofuranosyl]-5-phenylpyrrolo[2,3-d]pyrimidine

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Chemical Property of 4-amino-7-[2-deoxy-2,2-difluoro-α-D-erythro-pentofuranosyl]-5-phenylpyrrolo[2,3-d]pyrimidine

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Technology Process of 4-amino-7-[2-deoxy-2,2-difluoro-α-D-erythro-pentofuranosyl]-5-phenylpyrrolo[2,3-d]pyrimidine

There total 4 articles about 4-amino-7-[2-deoxy-2,2-difluoro-α-D-erythro-pentofuranosyl]-5-phenylpyrrolo[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1440537-05-2
4-amino-7-[2-deoxy-2,2-difluoro-a-d-erythro-pentofuranosyl]-5-iodopyrrolo[2,3-d]pyrimidine

: 98-80-6
phenylboronic acid

: 1440537-19-8
4-amino-7-[2-deoxy-2,2-difluoro-α-D-erythro-pentofuranosyl]-5-phenylpyrrolo[2,3-d]pyrimidine

Guidance literature:: With trisodium tris(3-sulfophenyl)phosphine; palladium diacetate; sodium carbonate; In water; acetonitrile; at 100 ℃; for 2h; Inert atmosphere;
DOI:10.1002/cmdc.201300047

Reference yield:

: 134877-42-2,134877-43-3,122111-11-9
3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-1-O-methanesulfonyl-D-erythro-pentofuranose

: 1440537-19-8
4-amino-7-[2-deoxy-2,2-difluoro-α-D-erythro-pentofuranosyl]-5-phenylpyrrolo[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: Tris(3,6-dioxaheptyl)amine; potassium hydroxide / acetonitrile / 96 h / 50 °C

2: ammonium hydroxide / 1,4-dioxane / 20 h / 120 °C

3: sodium carbonate; palladium diacetate; trisodium tris(3-sulfophenyl)phosphine / water; acetonitrile / 2 h / 100 °C / Inert atmosphere

With ammonium hydroxide; Tris(3,6-dioxaheptyl)amine; trisodium tris(3-sulfophenyl)phosphine; palladium diacetate; sodium carbonate; potassium hydroxide; In 1,4-dioxane; water; acetonitrile; 3: |Suzuki Coupling;
DOI:10.1002/cmdc.201300047

Reference yield:

: 1440537-03-0
4-chloro-7-[3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-α-D-erythro-pentofuranosyl]-5-iodopyrrolo[2,3-d]pyrimidine

: 1440537-19-8
4-amino-7-[2-deoxy-2,2-difluoro-α-D-erythro-pentofuranosyl]-5-phenylpyrrolo[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium hydroxide / 1,4-dioxane / 20 h / 120 °C

2: sodium carbonate; palladium diacetate; trisodium tris(3-sulfophenyl)phosphine / water; acetonitrile / 2 h / 100 °C / Inert atmosphere

With ammonium hydroxide; trisodium tris(3-sulfophenyl)phosphine; palladium diacetate; sodium carbonate; In 1,4-dioxane; water; acetonitrile; 2: |Suzuki Coupling;
DOI:10.1002/cmdc.201300047