5-bromo-3-{2-[(2-tert-butyl-phenylaminooxalyl)-amino]-propionylamino}-4-oxo-pentanoic acid tert-butyl ester

Base Information

Chemical Name:5-bromo-3-{2-[(2-tert-butyl-phenylaminooxalyl)-amino]-propionylamino}-4-oxo-pentanoic acid tert-butyl ester
CAS No.:868565-89-3
Molecular Formula:C₂₄H₃₄BrN₃O₆
Molecular Weight:540.454
Hs Code.:

5-bromo-3-{2-[(2-<i>tert</i>-butyl-phenylaminooxalyl)-amino]-propionylamino}-4-oxo-pentanoic acid <i>tert</i>-butyl ester

Synonyms:5-bromo-3-{2-[(2-tert-butyl-phenylaminooxalyl)-amino]-propionylamino}-4-oxo-pentanoic acid tert-butyl ester

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Chemical Property of 5-bromo-3-{2-[(2-tert-butyl-phenylaminooxalyl)-amino]-propionylamino}-4-oxo-pentanoic acid tert-butyl ester

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Technology Process of 5-bromo-3-{2-[(2-tert-butyl-phenylaminooxalyl)-amino]-propionylamino}-4-oxo-pentanoic acid tert-butyl ester

There total 5 articles about 5-bromo-3-{2-[(2-tert-butyl-phenylaminooxalyl)-amino]-propionylamino}-4-oxo-pentanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-{2-[(2-tert-butyl-phenylaminooxalyl)-amino]-propionylamino}-succinic acid 4-tert-butyl ester 1-methyl ester

: 868565-89-3
5-bromo-3-{2-[(2-tert-butyl-phenylaminooxalyl)-amino]-propionylamino}-4-oxo-pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: aq. LiOH / dioxane / 1 h / 20 °C

2.1: isobutyl chloroformate; N-methylmorpholine / tetrahydrofuran / 0.5 h / -10 °C

2.2: diethyl ether; tetrahydrofuran / 0.25 h / 0 °C

3.1: aq. HBr / tetrahydrofuran; diethyl ether / 0.25 h / 0 °C

With 4-methyl-morpholine; lithium hydroxide; hydrogen bromide; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; diethyl ether;
DOI:10.1021/jm050307e

Reference yield:

: 868565-78-0
2-{2-[(2-tert-butyl-phenylaminooxalyl)-amino]-propionylamino}-succinic acid 4-tert-butyl ester

: 868565-89-3
5-bromo-3-{2-[(2-tert-butyl-phenylaminooxalyl)-amino]-propionylamino}-4-oxo-pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: isobutyl chloroformate; N-methylmorpholine / tetrahydrofuran / 0.5 h / -10 °C

1.2: diethyl ether; tetrahydrofuran / 0.25 h / 0 °C

2.1: aq. HBr / tetrahydrofuran; diethyl ether / 0.25 h / 0 °C

With 4-methyl-morpholine; hydrogen bromide; isobutyl chloroformate; In tetrahydrofuran; diethyl ether;
DOI:10.1021/jm050307e

Reference yield:

: 6310-21-0
2-(1,1-dimethylethyl)-benzenamine

: 868565-89-3
5-bromo-3-{2-[(2-tert-butyl-phenylaminooxalyl)-amino]-propionylamino}-4-oxo-pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 70 percent / Et₃N / CH₂Cl₂ / 1 h / 0 - 20 °C

2.1: 58 percent / aq. LiOH / dioxane / 1 h / 20 °C

3.1: HATU; DIEA; N-methylmorpholine / CH₂Cl₂ / 2 h / 20 °C

4.1: aq. LiOH / dioxane / 1 h / 20 °C

5.1: isobutyl chloroformate; N-methylmorpholine / tetrahydrofuran / 0.5 h / -10 °C

5.2: diethyl ether; tetrahydrofuran / 0.25 h / 0 °C

6.1: aq. HBr / tetrahydrofuran; diethyl ether / 0.25 h / 0 °C

With 4-methyl-morpholine; lithium hydroxide; hydrogen bromide; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane;
DOI:10.1021/jm050307e