(2R,3R)-3-(tert-Butyl-diphenyl-silanyloxy)-5-(4-methoxy-benzyloxy)-2-methyl-pentanal

Base Information

Chemical Name:(2R,3R)-3-(tert-Butyl-diphenyl-silanyloxy)-5-(4-methoxy-benzyloxy)-2-methyl-pentanal
CAS No.:182284-84-0
Molecular Formula:C₃₀H₃₈O₄Si
Molecular Weight:490.715
Hs Code.:

Synonyms:(2R,3R)-3-(tert-Butyl-diphenyl-silanyloxy)-5-(4-methoxy-benzyloxy)-2-methyl-pentanal

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Chemical Property of (2R,3R)-3-(tert-Butyl-diphenyl-silanyloxy)-5-(4-methoxy-benzyloxy)-2-methyl-pentanal

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Technology Process of (2R,3R)-3-(tert-Butyl-diphenyl-silanyloxy)-5-(4-methoxy-benzyloxy)-2-methyl-pentanal

There total 4 articles about (2R,3R)-3-(tert-Butyl-diphenyl-silanyloxy)-5-(4-methoxy-benzyloxy)-2-methyl-pentanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2S,3R)-3-[2-(4-Methoxy-benzyloxy)-ethyl]-2-methyl-oxirane-2-carbaldehyde

: 182284-84-0
(2R,3R)-3-(tert-Butyl-diphenyl-silanyloxy)-5-(4-methoxy-benzyloxy)-2-methyl-pentanal

Guidance literature:: Multi-step reaction with 4 steps

1: 73 percent / 18-Crown-6, KN(TMS)2 / tetrahydrofuran / -78 °C

2: 84 percent / n-Bu₃P, HCO₂H-Et₃N / Pd₂(dba)3*CHCl₃ / dioxane / Ambient temperature

3: 100 percent / imidazole / dimethylformamide / Ambient temperature

4: 1.) OsO₄, NMO, 2.) Pb(OAc)4 / 1.) t-BuOH, acetone, H₂O, r.t., 2.) toluene, r.t.

With 1H-imidazole; lead(IV) acetate; osmium(VIII) oxide; formic acid; N-methyl-2-indolinone; 18-crown-6 ether; tributylphosphine; potassium hexamethylsilazane; triethylamine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(96)01460-8

Reference yield:

: 182284-82-8
(Z)-3-{(2R,3R)-3-[2-(4-Methoxy-benzyloxy)-ethyl]-2-methyl-oxiranyl}-acrylic acid methyl ester

: 182284-84-0
(2R,3R)-3-(tert-Butyl-diphenyl-silanyloxy)-5-(4-methoxy-benzyloxy)-2-methyl-pentanal

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / n-Bu₃P, HCO₂H-Et₃N / Pd₂(dba)3*CHCl₃ / dioxane / Ambient temperature

2: 100 percent / imidazole / dimethylformamide / Ambient temperature

3: 1.) OsO₄, NMO, 2.) Pb(OAc)4 / 1.) t-BuOH, acetone, H₂O, r.t., 2.) toluene, r.t.

With 1H-imidazole; lead(IV) acetate; osmium(VIII) oxide; formic acid; N-methyl-2-indolinone; tributylphosphine; triethylamine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(96)01460-8

Reference yield:

: 182284-83-9
(E)-(4S,5R)-5-Hydroxy-7-(4-methoxy-benzyloxy)-4-methyl-hept-2-enoic acid methyl ester

: 182284-84-0
(2R,3R)-3-(tert-Butyl-diphenyl-silanyloxy)-5-(4-methoxy-benzyloxy)-2-methyl-pentanal

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / imidazole / dimethylformamide / Ambient temperature

2: 1.) OsO₄, NMO, 2.) Pb(OAc)4 / 1.) t-BuOH, acetone, H₂O, r.t., 2.) toluene, r.t.

With 1H-imidazole; lead(IV) acetate; osmium(VIII) oxide; N-methyl-2-indolinone; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(96)01460-8