3-Methoxyphenylmagnesium bromide

Base Information

• Chemical Name: 3-Methoxyphenylmagnesium bromide
• CAS No.: 36282-40-3
• Molecular Formula: C7H7BrMgO
• Molecular Weight: 211.341
• Hs Code.: 29319090
• European Community (EC) Number: 627-089-4
• Mol file: 36282-40-3.mol

Synonyms:3-methoxyphenylmagnesium bromide;36282-40-3;(3-methoxyphenyl)magnesium bromide;MFCD00672002;3-Methoxyphenylmagnesium bromide, 1.0 M in THF;magnesium;methoxybenzene;bromide;3-Methoxyphenyl magnesium bromide;SCHEMBL24031;3- Methoxyphenylmagnesiumbromid;bromo(3-methoxyphenyl)magnesium;3-methoxy phenylmagnesium bromide;3-methoxyphenyl-magnesium bromide;m-Methoxyphenyl magnesium bromide;3-methoxylphenyl magnesium bromide;AJKNYEHIJAMGHX-UHFFFAOYSA-M;3-methoxy-phenyl magnesium bromide;3-(methyloxy)phenylmagnesiumbromide;AKOS016018097;3-Methoxyphenylmagnesium bromide, 0.5 M in THF;3-Methoxyphenylmagnesium bromide, 1.0 M in 2-MeTHF;3-Methoxyphenylmagnesium bromide 0.5 M in Tetrahydrofuran

Chemical Property of 3-Methoxyphenylmagnesium bromide

Chemical Property:

• Appearance/Colour: Clear colorless to brown solution
• Boiling Point: 65-67 °C
• Flash Point: −4 °F
• PSA: 9.23000
• Density: 1.013 g/mL at 25 °C
• LogP: 2.34100
• Sensitive.: Air & Moisture Sensitive
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 209.95307
• Heavy Atom Count: 10
• Complexity: 161

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Methoxyphenylmagnesium bromide solution 1.0 M in THF ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F; Xi
• Hazard Codes: F,C
• Statements: 11-14-19-20/21/22-34-37-40
• Safety Statements: 16-26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C[C-]=C1.[Mg+2].[Br-]

Technology Process of 3-Methoxyphenylmagnesium bromide

There total 5 articles about 3-Methoxyphenylmagnesium bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-methoxyphenyl bromide (2398-37-0) → (3-methoxyphenyl)magnesium bromide (36282-40-3)

Guidance literature:

With magnesium; iodine; In tetrahydrofuran; at 20 ℃; Heating / reflux;

Reference yield:

2,3-dihydro-4H-1-benzopyran-4-one (491-37-2) + 3-methoxyphenyl bromide (2398-37-0) → (3-methoxyphenyl)magnesium bromide (36282-40-3)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran;

Reference yield:

3-methoxyphenyl bromide (2398-37-0) + magnesium (7439-95-4) → (3-methoxyphenyl)magnesium bromide (36282-40-3)

Guidance literature:

In tetrahydrofuran;

upstream raw materials:

2,3-dihydro-4H-1-benzopyran-4-one

3-methoxyphenyl bromide

magnesium

Downstream raw materials:

2-(3-methoxyphenyl)-ethanol

1-(3-Methoxy-phenyl)-2-piperidinomethyl-cyclohexanol

3-(1-methyl-propenyl)-anisole

cis-3,3'-Dimethoxy-α,β-dimethylstilben

Refernces

• 1、 Li, Jie,Ren, Qianyi,Cheng, Xinyi,Karaghiosoff, Konstantin,Knochel, Paul. "Chromium(II)-Catalyzed Diastereoselective and Chemoselective Csp2-Csp3 Cross-Couplings Using Organomagnesium Reagents". supporting information. p. 18127 - 18135. Retrieved 2019/11/19.
• 2、 Fillion, Eric,Beaton, Eric,Nguyen, Yen,Wilsily, Ashraf,Bondarenko, Ganna,Jacq, Jér?me. "Facile Hydrogenolysis of C(sp3)–C(sp3) σ Bonds". supporting information. p. 3422 - 3434. Retrieved 2016/11/13.