(1S,2S)-2-aminomethyl-1-benzyloxycarbonylamino-1-cyclopropanecarboxylic acid methyl ester

Base Information

Chemical Name:(1S,2S)-2-aminomethyl-1-benzyloxycarbonylamino-1-cyclopropanecarboxylic acid methyl ester
CAS No.:151074-60-1
Molecular Formula:C₁₄H₁₈N₂O₄
Molecular Weight:278.308
Hs Code.:

Synonyms:(1S,2S)-2-aminomethyl-1-benzyloxycarbonylamino-1-cyclopropanecarboxylic acid methyl ester

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Chemical Property of (1S,2S)-2-aminomethyl-1-benzyloxycarbonylamino-1-cyclopropanecarboxylic acid methyl ester

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Technology Process of (1S,2S)-2-aminomethyl-1-benzyloxycarbonylamino-1-cyclopropanecarboxylic acid methyl ester

There total 5 articles about (1S,2S)-2-aminomethyl-1-benzyloxycarbonylamino-1-cyclopropanecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 151074-59-8
(1S,2S)-1-benzyloxycarbonylamino-2-(N-phthalimido)methyl-1-cyclopropanecarboxylic acid methyl ester

: 151074-60-1
(1S,2S)-2-aminomethyl-1-benzyloxycarbonylamino-1-cyclopropanecarboxylic acid methyl ester

Guidance literature:: With hydrazine hydrate; In methanol; chloroform; for 24h; Ambient temperature;
DOI:10.1016/S0040-4020(01)80152-6

Reference yield:

: 114498-10-1
(1S,2R)-1-Amino-2-hydroxymethyl-cyclopropanecarboxylic acid methyl ester

: 151074-60-1
(1S,2S)-2-aminomethyl-1-benzyloxycarbonylamino-1-cyclopropanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / 1 M aq. Na₂CO₃ / 4 h / 0 °C

2: 73 percent / diethyl azodicarboxylate, Ph₃P / tetrahydrofuran / Ambient temperature

3: 84 percent / hydrazine hydrate / methanol; CHCl₃ / 24 h / Ambient temperature

With sodium carbonate; hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; chloroform;
DOI:10.1016/S0040-4020(01)80152-6

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 151074-60-1
(1S,2S)-2-aminomethyl-1-benzyloxycarbonylamino-1-cyclopropanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / 1 M aq. Na₂CO₃ / 4 h / 0 °C

2: 73 percent / diethyl azodicarboxylate, Ph₃P / tetrahydrofuran / Ambient temperature

3: 84 percent / hydrazine hydrate / methanol; CHCl₃ / 24 h / Ambient temperature

With sodium carbonate; hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; chloroform;
DOI:10.1016/S0040-4020(01)80152-6