N^α-tert-butoxycarbonyl-N^im-2,4-dinitrophenyl-L-histidyl-L-leucyl-O-benzyl-L-tyrosine benzyl ester

Base Information

• Chemical Name: N^α-tert-butoxycarbonyl-N^im-2,4-dinitrophenyl-L-histidyl-L-leucyl-O-benzyl-L-tyrosine benzyl ester
• CAS No.: 226545-68-2
• Molecular Formula: C₄₆H₅₁N₇O₁₁
• Molecular Weight: 877.951

Synonyms:N^α-tert-butoxycarbonyl-N^im-2,4-dinitrophenyl-L-histidyl-L-leucyl-O-benzyl-L-tyrosine benzyl ester

Chemical Property of N^α-tert-butoxycarbonyl-N^im-2,4-dinitrophenyl-L-histidyl-L-leucyl-O-benzyl-L-tyrosine benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N^α-tert-butoxycarbonyl-N^im-2,4-dinitrophenyl-L-histidyl-L-leucyl-O-benzyl-L-tyrosine benzyl ester

There total 7 articles about N^α-tert-butoxycarbonyl-N^im-2,4-dinitrophenyl-L-histidyl-L-leucyl-O-benzyl-L-tyrosine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

Boc-His(Dnp)-OH (25024-53-7) + L-leucyl-O-benzyl-L-tyrosine benzyl ester hydrochloride → Nα-tert-butoxycarbonyl-Nim-2,4-dinitrophenyl-L-histidyl-L-leucyl-O-benzyl-L-tyrosine benzyl ester (226545-68-2)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; isopropylamine; isopropyl alcohol; In N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1248/cpb.47.563

Reference yield:

N-tert-butoxycarbonyl-L-leucine (13139-15-6,53296-34-7) → Nα-tert-butoxycarbonyl-Nim-2,4-dinitrophenyl-L-histidyl-L-leucyl-O-benzyl-L-tyrosine benzyl ester (226545-68-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 87 percent / N-methylmorpholine, 1-hydroxybenzotriazole, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / Ambient temperature

2: 100 percent / 4 N HCl / dioxane / Ambient temperature

3: 90 percent / isopropyl amine isopropanol, N-methylmorpholine, 1-hydroxybenzotriazole, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; isopropylamine; isopropyl alcohol; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1248/cpb.47.563

Reference yield:

O-benzyl-N-tert-butoxycarbonyl-L-tyrosine (2130-96-3,54784-43-9) → Nα-tert-butoxycarbonyl-Nim-2,4-dinitrophenyl-L-histidyl-L-leucyl-O-benzyl-L-tyrosine benzyl ester (226545-68-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 79 percent / dimethylaminopyridine, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 14 h / Ambient temperature

2: 98 percent / 4 N HCl / dioxane / Ambient temperature

3: 87 percent / N-methylmorpholine, 1-hydroxybenzotriazole, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / Ambient temperature

4: 100 percent / 4 N HCl / dioxane / Ambient temperature

5: 90 percent / isopropyl amine isopropanol, N-methylmorpholine, 1-hydroxybenzotriazole, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; isopropylamine; isopropyl alcohol; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1248/cpb.47.563

upstream raw materials:

Boc-His(Dnp)-OH

N-tert-butoxycarbonyl-L-leucine

O-benzyl-N-tert-butoxycarbonyl-L-tyrosine

H-Tyr(Bzl)-OBzl_.HCl

Downstream raw materials:

N^α-tert-butoxycarbonyl-L-prolyl-L-isoleucyl-glycyl-N^im-2,4-dinitrophenyl-L-histidyl-L-leucyl-O-benzyl-L-tyrosine benzyl ester

N^α-tert-butoxycarbonyl-L-isoleucyl-glycyl-N^im-2,4-dinitrophenyl-L-histidyl-L-leucyl-O-benzyl-L-tyrosine benzyl ester

L-isoleucyl-glycyl-N^im-2,4-dinitrophenyl-L-histidyl-L-leucyl-O-benzyl-L-tyrosine benzyl ester hydrochloride

N^α-tert-butoxycarbonylglycyl-N^im-2,4-dinitrophenyl-L-histidyl-L-leucyl-O-benzyl-L-tyrosine benzyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 226545-68-2 N^α-tert-butoxycarbonyl-N^im-2,4-dinitrophenyl-L-histidyl-L-leucyl-O-benzyl-L-tyrosine benzyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send