(3R,E)-3-amino-3-(2-naphthyl)-1-phenylsulfonyl-1-propene trifluoroacetate salt

Base Information

Chemical Name:(3R,E)-3-amino-3-(2-naphthyl)-1-phenylsulfonyl-1-propene trifluoroacetate salt
CAS No.:1253912-02-5
Molecular Formula:C₂HF₃O₂*C₁₉H₁₇NO₂S
Molecular Weight:437.439
Hs Code.:

Synonyms:(3R,E)-3-amino-3-(2-naphthyl)-1-phenylsulfonyl-1-propene trifluoroacetate salt

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Chemical Property of (3R,E)-3-amino-3-(2-naphthyl)-1-phenylsulfonyl-1-propene trifluoroacetate salt

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Technology Process of (3R,E)-3-amino-3-(2-naphthyl)-1-phenylsulfonyl-1-propene trifluoroacetate salt

There total 7 articles about (3R,E)-3-amino-3-(2-naphthyl)-1-phenylsulfonyl-1-propene trifluoroacetate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1253911-91-9
(3R,E)-3-(tert-butoxycarbonylamino)-3-(2-naphthyl)-1-phenylsulfonyl-1-propene

: 76-05-1
trifluoroacetic acid

: 1253912-02-5
(3R,E)-3-amino-3-(2-naphthyl)-1-phenylsulfonyl-1-propene trifluoroacetate salt

Guidance literature:: In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1002/cmdc.201000109

Reference yield:

: (2S,3R)-2,3-epoxy-3-(2-naphthyl)propanol

: 1253912-02-5
(3R,E)-3-amino-3-(2-naphthyl)-1-phenylsulfonyl-1-propene trifluoroacetate salt

Guidance literature:: Multi-step reaction with 7 steps

1: sodium azide; lithium perchlorate / acetonitrile / 3 h / 65 °C

2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 27 h / 20 °C / 760.05 Torr

3: di-isopropyl azodicarboxylate; triphenylphosphine / chloroform / 4.5 h / Reflux

4: triethylamine / methanol / 1 h / Inert atmosphere; Reflux

5: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1.5 h / 20 °C

6: N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; copper dichloride / acetonitrile / 0.5 h / 70 °C

7: dichloromethane / 0.5 h / 20 °C

With sodium azide; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; hydrogen; lithium perchlorate; N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; copper dichloride; In methanol; dichloromethane; chloroform; ethyl acetate; acetonitrile;
DOI:10.1002/cmdc.201000109

Reference yield:

: 1353747-97-3
(2S,3S)-3-(tert-butoxycarbonylamino)-3-(2-naphthyl)propane-1,2-diol

: 1253912-02-5
(3R,E)-3-amino-3-(2-naphthyl)-1-phenylsulfonyl-1-propene trifluoroacetate salt

Guidance literature:: Multi-step reaction with 5 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / chloroform / 4.5 h / Reflux

2: triethylamine / methanol / 1 h / Inert atmosphere; Reflux

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1.5 h / 20 °C

4: N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; copper dichloride / acetonitrile / 0.5 h / 70 °C

5: dichloromethane / 0.5 h / 20 °C

With di-isopropyl azodicarboxylate; N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; copper dichloride; In methanol; dichloromethane; chloroform; acetonitrile;
DOI:10.1002/cmdc.201000109