((3aR,4R,6R,6aR)-2,2-dimethyl-6-(9H-purin-9-yl)tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol

Base Information

• Chemical Name: ((3aR,4R,6R,6aR)-2,2-dimethyl-6-(9H-purin-9-yl)tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol
• CAS No.: 67604-85-7
• Molecular Formula: C₁₃H₁₆N₄O₄
• Molecular Weight: 292.294

Synonyms:((3aR,4R,6R,6aR)-2,2-dimethyl-6-(9H-purin-9-yl)tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol

Chemical Property of ((3aR,4R,6R,6aR)-2,2-dimethyl-6-(9H-purin-9-yl)tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol

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Technology Process of ((3aR,4R,6R,6aR)-2,2-dimethyl-6-(9H-purin-9-yl)tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol

There total 1 articles about ((3aR,4R,6R,6aR)-2,2-dimethyl-6-(9H-purin-9-yl)tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

1-amino-2',3'-O-isopropylideneadenosine mesitylenesulphonate → ((3aR,4R,6R,6aR)-2,2-dimethyl-6-(9H-purin-9-yl)tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol (67604-85-7) + 2',3'-isopropylidene adenosine (362-75-4)

Guidance literature:

With ammonia; In methanol; at 50 ℃; for 5h;

Reference yield: 38.0%

((3aR,4R,6R,6aR)-2,2-dimethyl-6-(9H-purin-9-yl)tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol (67604-85-7) + phenylboronic acid (98-80-6) → ((3aS,4R,6R,6aS)-2,2-dimethyl-6-(6-phenyl-9H-purin-9-yl)tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol

Guidance literature:

With ammonium peroxydisulfate; silver nitrate; trifluoroacetic acid; In water; 1,2-dichloro-ethane; for 3h; under 760.051 Torr; regioselective reaction;

DOI:10.1002/ejoc.201700406

Reference yield:

N-methyl-2-nitrobenzenesulfonamide (23530-40-7) + ((3aR,4R,6R,6aR)-2,2-dimethyl-6-(9H-purin-9-yl)tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol (67604-85-7) → C20H22N6O7S

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1016/j.bmc.2017.07.063

Downstream raw materials:

inosine 5'-monophosphate

(S)-4-Benzyloxycarbonylamino-5-[((2R,3S,4R,5R)-3,4-dihydroxy-5-purin-9-yl-tetrahydro-furan-2-ylmethoxy)-methoxy-phosphoryloxy]-pentanoic acid benzyl ester

(S)-4-Benzyloxycarbonylamino-5-[((3aR,4R,6R,6aR)-2,2-dimethyl-6-purin-9-yl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethoxy)-methoxy-phosphoryloxy]-pentanoic acid benzyl ester

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