Trifluoro-methanesulfonic acid (2R,4aR,6R,7R,8S,8aR)-6-benzyloxy-7-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester

Base Information

Chemical Name:Trifluoro-methanesulfonic acid (2R,4aR,6R,7R,8S,8aR)-6-benzyloxy-7-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester
CAS No.:176167-79-6
Molecular Formula:C₂₉H₂₄F₃NO₉S
Molecular Weight:619.572
Hs Code.:

Trifluoro-methanesulfonic acid (2R,4aR,6R,7R,8S,8aR)-6-benzyloxy-7-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester

Synonyms:Trifluoro-methanesulfonic acid (2R,4aR,6R,7R,8S,8aR)-6-benzyloxy-7-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester

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Chemical Property of Trifluoro-methanesulfonic acid (2R,4aR,6R,7R,8S,8aR)-6-benzyloxy-7-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester

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Technology Process of Trifluoro-methanesulfonic acid (2R,4aR,6R,7R,8S,8aR)-6-benzyloxy-7-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester

There total 9 articles about Trifluoro-methanesulfonic acid (2R,4aR,6R,7R,8S,8aR)-6-benzyloxy-7-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 85-44-9
phthalic anhydride

: 176167-79-6
Trifluoro-methanesulfonic acid (2R,4aR,6R,7R,8S,8aR)-6-benzyloxy-7-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: CHCl₃ / 1 h / Ambient temperature

2: Ac₂O / pyridine / 5 h / Heating

3: pyridine / CH₂Cl₂ / 0.5 h / -30 °C

With pyridine; acetic anhydride; In pyridine; dichloromethane; chloroform;
DOI:10.1039/CC9960000127

Reference yield:

: 358-23-6
trifluoromethylsulfonic anhydride

: 176300-17-7
2-((2R,4aR,6R,7R,8S,8aS)-6-Benzyloxy-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl)-isoindole-1,3-dione

: 176167-79-6
Trifluoro-methanesulfonic acid (2R,4aR,6R,7R,8S,8aR)-6-benzyloxy-7-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester

Guidance literature:: With pyridine; In dichloromethane; at -30 ℃; for 0.5h;
DOI:10.1039/CC9960000127

Reference yield:

: 1125-88-8
benzaldehyde dimethyl acetal

: 176167-79-6
Trifluoro-methanesulfonic acid (2R,4aR,6R,7R,8S,8aR)-6-benzyloxy-7-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: p-TsOH / acetonitrile / 2 h / Ambient temperature

2: KOH / methanol / 20 h / 125 °C

3: CHCl₃ / 1 h / Ambient temperature

4: Ac₂O / pyridine / 5 h / Heating

5: pyridine / CH₂Cl₂ / 0.5 h / -30 °C

With pyridine; potassium hydroxide; acetic anhydride; toluene-4-sulfonic acid; In pyridine; methanol; dichloromethane; chloroform; acetonitrile;
DOI:10.1039/CC9960000127