5-methyl hydrogen 9-isopropyl-1-[(E)-2-(4-methoxyphenyl)ethenyl]-6-methylheptalene-4,5-dicarboxylate

Base Information

Chemical Name:5-methyl hydrogen 9-isopropyl-1-[(E)-2-(4-methoxyphenyl)ethenyl]-6-methylheptalene-4,5-dicarboxylate
CAS No.:1454588-94-3
Molecular Formula:C₂₈H₂₈O₅
Molecular Weight:444.527
Hs Code.:

Synonyms:5-methyl hydrogen 9-isopropyl-1-[(E)-2-(4-methoxyphenyl)ethenyl]-6-methylheptalene-4,5-dicarboxylate

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Chemical Property of 5-methyl hydrogen 9-isopropyl-1-[(E)-2-(4-methoxyphenyl)ethenyl]-6-methylheptalene-4,5-dicarboxylate

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Technology Process of 5-methyl hydrogen 9-isopropyl-1-[(E)-2-(4-methoxyphenyl)ethenyl]-6-methylheptalene-4,5-dicarboxylate

There total 6 articles about 5-methyl hydrogen 9-isopropyl-1-[(E)-2-(4-methoxyphenyl)ethenyl]-6-methylheptalene-4,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: dimethyl 9-isopropyl-1-[(E)-2-(4-methoxyphenyl)ethenyl]-6-methylheptalene-4,5-dicarboxylate

: 1454588-94-3
5-methyl hydrogen 9-isopropyl-1-[(E)-2-(4-methoxyphenyl)ethenyl]-6-methylheptalene-4,5-dicarboxylate

Guidance literature:: With lithium hydroxide; In methanol; water; at 70 ℃; for 2h;
DOI:10.1002/hlca.201300137

Reference yield:

: 188635-39-4
dimethyl 1-(chloromethyl)-9-isopropyl-6-methylheptalene-4,5-dicarboxylate

: 1454588-94-3
5-methyl hydrogen 9-isopropyl-1-[(E)-2-(4-methoxyphenyl)ethenyl]-6-methylheptalene-4,5-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium iodide / acetone / 1 h / 20 °C / Inert atmosphere

2.1: dichloromethane / 0.67 h / 90 - 100 °C / 300 - 450 Torr

3.1: sodium hexamethyldisilazane / tetrahydrofuran / -78 °C / Inert atmosphere

3.2: 12 h / -78 - 20 °C / Inert atmosphere

4.1: lithium hydroxide / methanol; water / 2 h / 70 °C

With sodium hexamethyldisilazane; sodium iodide; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; acetone; 1.1: |Finkelstein Reaction / 2.1: |Michaelis-Arbuzov Synthesis / 3.1: |Horner-Wadsworth-Emmons Olefination / 3.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1002/hlca.201300137

Reference yield:

: 188635-40-7
dimethyl 1-(iodomethyl)-9-isopropyl-6-methylheptalene-4,5-dicarboxylate

: 1454588-94-3
5-methyl hydrogen 9-isopropyl-1-[(E)-2-(4-methoxyphenyl)ethenyl]-6-methylheptalene-4,5-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloromethane / 0.67 h / 90 - 100 °C / 300 - 450 Torr

2.1: sodium hexamethyldisilazane / tetrahydrofuran / -78 °C / Inert atmosphere

2.2: 12 h / -78 - 20 °C / Inert atmosphere

3.1: lithium hydroxide / methanol; water / 2 h / 70 °C

With sodium hexamethyldisilazane; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; 1.1: |Michaelis-Arbuzov Synthesis / 2.1: |Horner-Wadsworth-Emmons Olefination / 2.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1002/hlca.201300137