2-((3-acetyl-1-(2-methylbenzyl)-1,4-dihydropyridin-4-yl)methyl)-6-methoxy-3,4-dihydronaphthalen-1(2H)-one

Base Information

Chemical Name:2-((3-acetyl-1-(2-methylbenzyl)-1,4-dihydropyridin-4-yl)methyl)-6-methoxy-3,4-dihydronaphthalen-1(2H)-one
CAS No.:1620645-80-8
Molecular Formula:C₂₇H₂₉NO₃
Molecular Weight:415.532
Hs Code.:

Synonyms:2-((3-acetyl-1-(2-methylbenzyl)-1,4-dihydropyridin-4-yl)methyl)-6-methoxy-3,4-dihydronaphthalen-1(2H)-one

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Chemical Property of 2-((3-acetyl-1-(2-methylbenzyl)-1,4-dihydropyridin-4-yl)methyl)-6-methoxy-3,4-dihydronaphthalen-1(2H)-one

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Technology Process of 2-((3-acetyl-1-(2-methylbenzyl)-1,4-dihydropyridin-4-yl)methyl)-6-methoxy-3,4-dihydronaphthalen-1(2H)-one

There total 5 articles about 2-((3-acetyl-1-(2-methylbenzyl)-1,4-dihydropyridin-4-yl)methyl)-6-methoxy-3,4-dihydronaphthalen-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1620644-99-6
2-((3-acetyl-1-(2-methylbenzyl)-1,4-dihydropyridin-4-yl)methyl)-6-methoxy-3,4-dihydronaphthalen-1(2H)-one

: 1620645-81-9
2-((3-acetyl-1-(2-methylbenzyl)-1,4-dihydropyridin-4-yl)methyl)-6-methoxy-3,4-dihydronaphthalen-1(2H)-one

: 1620645-80-8
2-((3-acetyl-1-(2-methylbenzyl)-1,4-dihydropyridin-4-yl)methyl)-6-methoxy-3,4-dihydronaphthalen-1(2H)-one

: 1620645-82-0
2-((3-acetyl-1-(2-methylbenzyl)-1,4-dihydropyridin-4-yl)methyl)-6-methoxy-3,4-dihydronaphthalen-1(2H)-one

: 1620645-83-1
2-((3-acetyl-1-(2-methylbenzyl)-1,4-dihydropyridin-4-yl)methyl)-6-methoxy-3,4-dihydronaphthalen-1(2H)-one

Guidance literature:: With IA column; In ethanol; carbon dioxide; Resolution of racemate; Supercritical conditions; liquid CO₂;

Reference yield:

: 1620646-15-2
(E)-4-(6-methoxy-1-oxo-tetralin-2-yl)but-2-enal

: (Z)-4-((2-methylbenzyl)amino)but-3-en-2-one

: 1620645-81-9
2-((3-acetyl-1-(2-methylbenzyl)-1,4-dihydropyridin-4-yl)methyl)-6-methoxy-3,4-dihydronaphthalen-1(2H)-one

: 1620645-80-8
2-((3-acetyl-1-(2-methylbenzyl)-1,4-dihydropyridin-4-yl)methyl)-6-methoxy-3,4-dihydronaphthalen-1(2H)-one

: 1620645-82-0
2-((3-acetyl-1-(2-methylbenzyl)-1,4-dihydropyridin-4-yl)methyl)-6-methoxy-3,4-dihydronaphthalen-1(2H)-one

: 1620645-83-1
2-((3-acetyl-1-(2-methylbenzyl)-1,4-dihydropyridin-4-yl)methyl)-6-methoxy-3,4-dihydronaphthalen-1(2H)-one

Guidance literature:: With (S)-2-{bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilanyl)oxy]methyl}pyrrolidine; saccharin; In 1,2-dichloro-ethane; at 40 ℃; Overall yield = 55%; Overall yield = 207.6 mg; stereoselective reaction; Inert atmosphere;
DOI:10.1021/acs.joc.8b01442

Reference yield:

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

: 1620645-81-9
2-((3-acetyl-1-(2-methylbenzyl)-1,4-dihydropyridin-4-yl)methyl)-6-methoxy-3,4-dihydronaphthalen-1(2H)-one

: 1620645-80-8
2-((3-acetyl-1-(2-methylbenzyl)-1,4-dihydropyridin-4-yl)methyl)-6-methoxy-3,4-dihydronaphthalen-1(2H)-one

: 1620645-82-0
2-((3-acetyl-1-(2-methylbenzyl)-1,4-dihydropyridin-4-yl)methyl)-6-methoxy-3,4-dihydronaphthalen-1(2H)-one

: 1620645-83-1
2-((3-acetyl-1-(2-methylbenzyl)-1,4-dihydropyridin-4-yl)methyl)-6-methoxy-3,4-dihydronaphthalen-1(2H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

1.2: 0.08 h

1.3: -78 - 20 °C

2.1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 40 °C / Inert atmosphere

3.1: (S)-2-{bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilanyl)oxy]methyl}pyrrolidine; saccharin / 1,2-dichloro-ethane / 40 °C / Inert atmosphere

With (S)-2-{bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilanyl)oxy]methyl}pyrrolidine; Hoveyda-Grubbs catalyst second generation; saccharin; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/acs.joc.8b01442