1,3-bis(5-(4-(3,4,5-trimethoxybenzoyl-N-methylamino)phenyl)pyrrol-2-yl)-1,3-propanedione

Base Information

Chemical Name:1,3-bis(5-(4-(3,4,5-trimethoxybenzoyl-N-methylamino)phenyl)pyrrol-2-yl)-1,3-propanedione
CAS No.:1315511-85-3
Molecular Formula:C₄₅H₄₄N₄O₁₀
Molecular Weight:800.865
Hs Code.:

Synonyms:1,3-bis(5-(4-(3,4,5-trimethoxybenzoyl-N-methylamino)phenyl)pyrrol-2-yl)-1,3-propanedione

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Chemical Property of 1,3-bis(5-(4-(3,4,5-trimethoxybenzoyl-N-methylamino)phenyl)pyrrol-2-yl)-1,3-propanedione

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Technology Process of 1,3-bis(5-(4-(3,4,5-trimethoxybenzoyl-N-methylamino)phenyl)pyrrol-2-yl)-1,3-propanedione

There total 6 articles about 1,3-bis(5-(4-(3,4,5-trimethoxybenzoyl-N-methylamino)phenyl)pyrrol-2-yl)-1,3-propanedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 1315511-82-0
2-(4-(3,4,5-trimethoxybenzoyl-N-methylamino)phenyl)pyrrole

: 1663-67-8
malonoyl dichloride

: 1315511-85-3
1,3-bis(5-(4-(3,4,5-trimethoxybenzoyl-N-methylamino)phenyl)pyrrol-2-yl)-1,3-propanedione

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 3h;
DOI:10.1039/c1cc12827b

Reference yield:

: 299950-93-9
N-(4-bromophenyl)-3,4,5-trimethoxybenzamide

: 1315511-85-3
1,3-bis(5-(4-(3,4,5-trimethoxybenzoyl-N-methylamino)phenyl)pyrrol-2-yl)-1,3-propanedione

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 4 h

1.2: 5 h / 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 6 h / Inert atmosphere; Reflux

3.1: 0.25 h / 190 °C / Neat (no solvent)

4.1: tetrahydrofuran / 3 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; sodium carbonate; In tetrahydrofuran; 1,2-dimethoxyethane; water; mineral oil;
DOI:10.1039/c1cc12827b

Reference yield:

: 1315511-76-2
methyl N-(4-bromophenyl)-3,4,5-trimethoxybenzamide

: 1315511-85-3
1,3-bis(5-(4-(3,4,5-trimethoxybenzoyl-N-methylamino)phenyl)pyrrol-2-yl)-1,3-propanedione

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 6 h / Inert atmosphere; Reflux

2: 0.25 h / 190 °C / Neat (no solvent)

3: tetrahydrofuran / 3 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; 1,2-dimethoxyethane; water;
DOI:10.1039/c1cc12827b