diethyl N-benzylphosphoramidate

Base Information

• Chemical Name: diethyl N-benzylphosphoramidate
• CAS No.: 53640-96-3
• Molecular Formula: C₁₁H₁₈NO₃P
• Molecular Weight: 243.243
• Mol file: 53640-96-3.mol

Synonyms:diethyl N-benzylphosphoramidate

Chemical Property of diethyl N-benzylphosphoramidate

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl N-benzylphosphoramidate

There total 22 articles about diethyl N-benzylphosphoramidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

phosphonic acid diethyl ester (762-04-9) + benzylamine (100-46-9) → diethyl N-benzylphosphoramidate (53640-96-3)

Guidance literature:

In tetrachloromethane; at 20 ℃;

DOI:10.1021/acs.orglett.5b00799

Reference yield: 98.0%

diethyl chlorophosphate (814-49-3) + benzylamine (100-46-9) → diethyl N-benzylphosphoramidate (53640-96-3)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

Reference yield: 95.0%

benzylamine (100-46-9) + triethyl phosphite (122-52-1) → diethyl N-benzylphosphoramidate (53640-96-3)

Guidance literature:

With iodine; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1039/c8ob01840e

upstream raw materials:

phosphonic acid diethyl ester

benzylamine

Diethyl phosphonate

N-(phenylmethyl)-2-benzothiazolesulfenamide

Downstream raw materials:

diethyl benzyl(oct-1-yn-1-yl)phosphoramidate

C₂₂H₃₈NO₃PSi

C₂₀H₃₄NO₄PSi

diethyl N-benzyl-N-[2-(methoxycarbonyl)ethyl]phosphoramidate

Refernces

• 1、 Data, Shailja,Leung Wai, Jeffery,Kumar, Saawan,Cameron, Alan J.,Trehet, Manon,Itumoh, Emeka J.,Feld, Joey,S?hnel, Tilo,Leitao, Erin M.. "The Step-Wise Synthesis of Oligomeric Phosphoramidates". supporting information. p. 5468 - 5477. Retrieved 2021/09/30.
• 2、 Ou, Yingcong,Huang, Yuanting,He, Zhenlin,Yu, Guodian,Huo, Yanping,Li, Xianwei,Gao, Yang,Chen, Qian. "A phosphoryl radical-initiated Atherton-Todd-type reaction under open air". supporting information. p. 1357 - 1360. Retrieved 2020/02/11.