Technology Process of (E,3S,4R,5S)-4,6-Dimethyl-5-<(p-methoxybenzyl)oxy>-7-<(1R,3R,4R)-3-methoxy-4-<(triisopropylsilyl)oxy>cyclohexyl>-6-hepten-1,3-diol
There total 5 articles about (E,3S,4R,5S)-4,6-Dimethyl-5-<(p-methoxybenzyl)oxy>-7-<(1R,3R,4R)-3-methoxy-4-<(triisopropylsilyl)oxy>cyclohexyl>-6-hepten-1,3-diol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium dihydro-bis-(2-methoxyethoxy)aluminate;
In
tetrahydrofuran; toluene;
at -5 ℃;
for 20h;
DOI:10.1021/jo00127a031
- Guidance literature:
-
Multi-step reaction with 4 steps
1: triflic acid / diethyl ether / 0.83 h / Ambient temperature
2: 91 percent / bis(2-methoxyethoxy)aluminium hydride / tetrahydrofuran; toluene / 15 h / 0 °C
3: 91 percent / molecular sieves, D-(-)-diethyl tartrate, Ti(Oi-Pr)4, TBHP / CH2Cl2 / 15 h / -22 °C
4: 89 percent / bis(2-methoxyethoxy)aluminium hydride / tetrahydrofuran; toluene / 20 h / -5 °C
With
titanium(IV) isopropylate; tert.-butylhydroperoxide; molecular sieve; diethyl (2S,3S)-tartrate; trifluorormethanesulfonic acid; sodium dihydro-bis-(2-methoxyethoxy)aluminate;
In
tetrahydrofuran; diethyl ether; dichloromethane; toluene;
DOI:10.1021/jo00127a031
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 91 percent / molecular sieves, D-(-)-diethyl tartrate, Ti(Oi-Pr)4, TBHP / CH2Cl2 / 15 h / -22 °C
2: 89 percent / bis(2-methoxyethoxy)aluminium hydride / tetrahydrofuran; toluene / 20 h / -5 °C
With
titanium(IV) isopropylate; tert.-butylhydroperoxide; molecular sieve; diethyl (2S,3S)-tartrate; sodium dihydro-bis-(2-methoxyethoxy)aluminate;
In
tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/jo00127a031
